| UniProt/SwissProt ID: | TYOBP_HUMAN |
| Description: | TYRO protein tyrosine kinase binding protein [Source:HGNC Symbol;Acc:12449] |
| Location: | chr19 q13.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y91 | ETESPyQELQG | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y91 | ETESPyQELQG | SYK | HPRD; phosphoELM; RegPhos |
| Y111 | NTQRPyYK___ | PhosphoSitePlus | |
| Y91 | ETESPyQELQG | Syk | RegPhos |
| Y112 | TQRPYyK____ | PhosphoSitePlus | |
| Y102 | QRSDVySDLNT | PhosphoSitePlus; RegPhos | |
| Y90 | ETESPyQELQG | SYK | HPRD |
| S89 | ITETEsPYQEL | PhosphoSitePlus | |
| Y102 | QRSDVySDLNT | SYK | HPRD; phosphoELM; RegPhos |
| Y102 | QRSDVySDLNT | Syk | RegPhos |
| Y101 | QRSDVySDLNT | SYK | HPRD |
| Dephosphorylation site |
| TYOBP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262629 | R23C | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| TYOBP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TYOBP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KSYK_HUMAN | TYOBP_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | TYOBP_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa04380 | Osteoclast differentiation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005057 | receptor signaling protein activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0002281 | macrophage activation involved in immune response | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006968 | cellular defense response | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | TAS | biological_process |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0002283 | neutrophil activation involved in immune response | IEA | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |