Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:B3AT_HUMAN
Description:solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) [Source:HGNC Symbol;Acc:11027]
Location:chr17 q21.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T49TDYHTtSHPGTPhosphoSitePlus; HPRD; RegPhos
Y21LEQEEyEDPDILynphosphoELM; RegPhos
Y8ELQDDyEDMMEPhosphoSitePlus; HPRD; RegPhos
T48ATDYHtTSHPGPhosphoSitePlus; HPRD; RegPhos
T42HDTEAtATDYHCK1_alphaphosphoELM
T42HDTEAtATDYHCK1a(CK1 alphaRegPhos
Y8ELQDDyEDMMELynphosphoELM; RegPhos
Y46ATATDyHTTSHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S781MEPILsRIPLAHCO3_cotranspPhosphoSitePlus
T44TEATAtDYHTTPhosphoSitePlus; HPRD; RegPhos
S350RRYQSsPAKPDRegPhos
Y359PDSSFyKGLDLLynphosphoELM; RegPhos
S303AYMAQsRGELLCK1_alphaphosphoELM
Y904EGRDEyDEVAMSykRegPhos
Y904EGRDEyDEVAMSYKHPRD; phosphoELM; RegPhos
Y818FKPPKyHPDVPHCO3_cotranspPhosphoSitePlus
S50DYHTTsHPGTHPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y359PDSSFyKGLDLLYNHPRD; RegPhos
T42HDTEAtATDYHPhosphoSitePlus; HPRD; RegPhos
S357AKPDSsFYKGLPhosphoSitePlus
Y21LEQEEyEDPDISykRegPhos
Y8ELQDDyEDMMELYNHPRD; RegPhos
Y21LEQEEyEDPDISYKHPRD; phosphoELM; RegPhos
Y8ELQDDyEDMMESYKHPRD; phosphoELM; RegPhos
S29PDIPEsQMEEPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y8ELQDDyEDMMESykRegPhos
T54TSHPGtHKVYVPhosphoSitePlus; HPRD; RegPhos
S303AYMAQsRGELLBand_3_cytoPhosphoSitePlus
Y21LEQEEyEDPDIPhosphoSitePlus; HPRD; RegPhos
Y347LLRRRyQSSPAPhosphoSitePlus
S303AYMAQsRGELLCK1a(CK1 alphaRegPhos
Y904EGRDEyDEVAMPhosphoSitePlus; phosphoELM; RegPhos
S356PAKPDsSFYKGPhosphoSitePlus
Y904EGRDEyDEVAMLynphosphoELM; RegPhos
Y904EGRDEyDEVAMLYNHPRD; RegPhos
Y359PDSSFyKGLDLPhosphoSitePlus; phosphoELM; RegPhos
T894DDAKAtFDEEEPhosphoSitePlus
S525TQEIFsFLISLTM; HCO3_cotranspPhosphoSitePlus
Y359PDSSFyKGLDLSYKHPRD; phosphoELM; RegPhos
Y359PDSSFyKGLDLSykRegPhos
T39PAAHDtEATATPhosphoSitePlus; HPRD; RegPhos
Y21LEQEEyEDPDILYNHPRD; RegPhos

Dephosphorylation site
B3AT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262418M11TCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262418Breast CancerNormal vs. CancertissueDown20560667

Hyperphosphorylation site
B3AT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1A_HUMANB3AT_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANB3AT_HUMANkinase -> substrateRegPhos
KSYK_HUMANB3AT_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LYN_HUMANB3AT_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04966Collecting duct acid secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005452inorganic anion exchanger activityTASmolecular_function
GO:0030018Z discISScellular_component
GO:0015108chloride transmembrane transporter activityISSmolecular_function
GO:0008022protein C-terminus bindingIEAmolecular_function
GO:0006810transportIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006873cellular ion homeostasisTASbiological_process
GO:0006821chloride transportIEAbiological_process
GO:0015701bicarbonate transportTASbiological_process
GO:0030506ankyrin bindingIPImolecular_function
GO:0015108chloride transmembrane transporter activityIEAmolecular_function
GO:0005887integral to plasma membraneIDAcellular_component
GO:0015301anion:anion antiporter activityIDAmolecular_function
GO:0008509anion transmembrane transporter activityTASmolecular_function
GO:0006820anion transportIDAbiological_process
GO:0005215transporter activityIEAmolecular_function
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0030863cortical cytoskeletonIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0043495protein anchorTASmolecular_function
GO:0016021integral to membraneNAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006811ion transportTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0006821chloride transportISSbiological_process
GO:0030863cortical cytoskeletonIDAcellular_component
GO:0016323basolateral plasma membraneIDAcellular_component
GO:0030018Z discIEAcellular_component
GO:0055085transmembrane transportTASbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0003779actin bindingIEAmolecular_function


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