Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:3BP2_HUMAN
Description:SH3-domain binding protein 2 [Source:HGNC Symbol;Acc:10825]
Location:chr4 p16.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S425GQSFRsFSFEKPhosphoSitePlus
T273PRVPAtPRRMSPhosphoSitePlus
Y183DEDDSyLEPDSPhosphoSitePlus; phosphoELM; RegPhos
S225MPRAHsFTSKGPKC_alphaphosphoELM
S444TGGDDsDEDYEPhosphoSitePlus
Y448DSDEDyEKVPLSYKHPRD; RegPhos
S336CDKLKsFHLSPPhosphoSitePlus
Y183DEDDSyLEPDSSYKHPRD; RegPhos
Y448DSDEDyEKVPLPhosphoSitePlus
S416PHLQRsPPDGQPhosphoSitePlus
S427SFRSFsFEKPRPhosphoSitePlus
S278TPRRMsDPPLSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S225MPRAHsFTSKGPhosphoSitePlus
Y174TDNEDyEHDDESYKHPRD; RegPhos
Y174TDNEDyEHDDEPhosphoSitePlus; phosphoELM; RegPhos
S225MPRAHsFTSKGPKCa(PKC alphaRegPhos
T39HKKGGtQLQLLPHPhosphoSitePlus

Dephosphorylation site
3BP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000409746P201TBIOMARTBreast Cancer21930507, 21930502
ENSP00000424846P201TBIOMARTBreast Cancer21930507, 21930502
ENSP00000388152P229TBIOMARTBreast Cancer21930507, 21930502
ENSP00000348685P201TBIOMARTBreast Cancer21930507, 21930502
ENSP00000403231P201TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
3BP2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
3BP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KSYK_HUMAN3BP2_HUMANkinase -> substrateRegPhos; NetPath
ZAGL2_HUMAN3BP2_HUMANkinase -> substrateRegPhos
KPCA_HUMAN3BP2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0005515protein bindingIPImolecular_function


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