Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CBLB_HUMAN
Description:Cbl proto-oncogene, E3 ubiquitin protein ligase B [Source:HGNC Symbol;Acc:1542]
Location:chr3 q13.11
Node attribute:ubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y363EQYELyCEMGSPhosphoSitePlus
S896QLPSCsDGSQAPhosphoSitePlus
S662NGHLGsEEYDVPhosphoSitePlus
S614LLGEGsPKPGIPhosphoSitePlus; HPRD
Y360VTQEQyELYCEPhosphoSitePlus
Y802RTPSDyDLLIPPhosphoSitePlus
T798SSLNRtPSDYDPhosphoSitePlus
Y763PDLSIyLKGDVPhosphoSitePlus
S529GSPTGsPKSSPPhosphoSitePlus; HPRD; phosphoELM
S886KTNRTsQDYDQPhosphoSitePlus
S521KGIVRsPCGSPPhosphoSitePlus; HPRD; phosphoELM
S476TDRQNsPVTSPPhosphoSitePlus; HPRD
S894YDQLPsCSDGSPhosphoSitePlus
Y889RTSQDyDQLPSPhosphoSitePlus; phosphoELM
S525RSPCGsPTGSPPhosphoSitePlus; HPRD; phosphoELM
Y665LGSEEyDVPPRPhosphoSitePlus
S282STKPGsYIFRLCbl_N3PhosphoSitePlus
Y337PDGRSyNPDLTCbl_N3PhosphoSitePlus
S483VTSPGsSPLAQPhosphoSitePlus; HPRD
Y106LSENEyFKIYICbl_NPhosphoSitePlus
Y92LILSKyDDNQKCbl_NPhosphoSitePlus
S484TSPGSsPLAQRPhosphoSitePlus; HPRD; phosphoELM
Y709EDDDEyKIPSSPhosphoSitePlus
T698SLSEKtRDPVEPhosphoSitePlus
T620PKPGItASSNVPhosphoSitePlus
S480NSPVTsPGSSPPhosphoSitePlus; HPRD; phosphoELM
T527PCGSPtGSPKSHPRD; phosphoELM
S672VPPRLsPPPPVPhosphoSitePlus
T882GENVKtNRTSQPhosphoSitePlus
T678PPPPVtTLLPSHPRD
T885VKTNRtSQDYDPhosphoSitePlus
T601RDVFGtNQLVGPhosphoSitePlus
S899SCSDGsQAPARPhosphoSitePlus
T679PPPVTtLLPSIHPRD
S277RLQKYsTKPGSCbl_N3PhosphoSitePlus

Dephosphorylation site
CBLB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264122G244CDing2008, COSMICLung Cancer18948947
ENSP00000264122R699GCOSMICLung Cancer20668451
ENSP00000264122I619MDing2008, COSMICLung Cancer18948947
ENSP00000264122P562LCOSMICBreast Cancer20668451
ENSP00000264122D759ECOSMICOvarian Cancer21720365
ENSP00000264122P509SCOSMICMelanoma
ENSP00000264122G848*COSMICLung Cancer20668451
ENSP00000264122P534SCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000264122Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineUp4.515169874

Hyperphosphorylation site
CBLB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CBLB_HUMANKSYK_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa04910Insulin signaling pathway
hsa04660T cell receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa05220Chronic myeloid leukemia
hsa04144Endocytosis
hsa04012ErbB signaling pathway
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0001784phosphotyrosine bindingIEAmolecular_function
GO:0006607NLS-bearing substrate import into nucleusTASbiological_process
GO:0046642negative regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0006955immune responseIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0045732positive regulation of protein catabolic processIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0002669positive regulation of T cell anergyIEAbiological_process
GO:0050860negative regulation of T cell receptor signaling pIEAbiological_process
GO:0042110T cell activationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004871signal transducer activityIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0005509calcium ion bindingIEAmolecular_function


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