| UniProt/SwissProt ID: | LPAR4_HUMAN |
| Description: | lysophosphatidic acid receptor 4 [Source:HGNC Symbol;Acc:4478] |
| Location: | chrX q21.1 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| LPAR4_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| LPAR4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362398 | D307Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362398 | D307N | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000408205 | D307Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000362398 | T109P | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000362398 | S14* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000408205 | D307Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362398 | D307Y | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000408205 | T109P | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000362398 | R195H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000408205 | S14* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000362398 | R195H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000408205 | R195H | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000408205 | R195H | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| LPAR4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LPAR4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LIPH_HUMAN | LPAR4_HUMAN | ligand -> receptor | HPMR |
| LPAR4_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR4_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR4_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| LPAR4_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0045028 | G-protein coupled purinergic nucleotide receptor a | IEA | molecular_function |
| GO:0008289 | lipid binding | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |