Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CRFR1_HUMAN
Description:corticotropin releasing hormone receptor 1 [Source:HGNC Symbol;Acc:2357]
Location:chr17 q21.31
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S330TKLRAsTTSET7tm_2PhosphoSitePlus
S330TKLRAsTTSETphosphoELM
S425VARAMsIPTSPPhosphoSitePlus
S434SPTRVsFHSIKPhosphoSitePlus
T442SIKQStAV___PhosphoSitePlus
S437RVSFHsIKQSTPhosphoSitePlus
S441HSIKQsTAV__PhosphoSitePlus

Dephosphorylation site
CRFR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000344068T263MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000326060R371HCOSMICLung Cancer20668451
ENSP00000326060V132LCOSMICLung Cancer20668451
ENSP00000326060T303MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381333R254WBIOMARTBreast Cancer21930507, 21930502
ENSP00000326060R96SCOSMICLung Cancer20668451
ENSP00000381333T332MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000326060R225WBIOMARTBreast Cancer21930507, 21930502
ENSP00000344068R185WBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
CRFR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CRFR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
UCN1_HUMANCRFR1_HUMANligand -> receptorHPMR
CRF_HUMANCRFR1_HUMANligand -> receptorHPMR
CRFR1_HUMANGNAS1_HUMANGPCR -> GproteingpDB
CRFR1_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GLHA_HUMANCRFR1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04730Long-term depression
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045177apical part of cellIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIEAbiological_process
GO:0007218neuropeptide signaling pathwayIEAbiological_process
GO:0043404corticotropin-releasing hormone receptor activityIEAmolecular_function
GO:0007189adenylate cyclase-activating G-protein coupled recIEAbiological_process
GO:0021854hypothalamus developmentIEAbiological_process
GO:0043306positive regulation of mast cell degranulationIEAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0032811negative regulation of epinephrine secretionIEAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0051424corticotropin-releasing hormone bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0009755hormone-mediated signaling pathwayIEAbiological_process
GO:0035641locomotory exploration behaviorIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0005771multivesicular bodyIEAcellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0032099negative regulation of appetiteIEAbiological_process
GO:0005802trans-Golgi networkIEAcellular_component
GO:0033267axon partIEAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0048148behavioral response to cocaineIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0035902response to immobilization stressIEAbiological_process
GO:0071376cellular response to corticotropin-releasing hormoIEAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0007565female pregnancyNASbiological_process
GO:0007610behaviorIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:1901215negative regulation of neuron deathIEAbiological_process
GO:0007567parturitionTASbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0006955immune responseTASbiological_process
GO:0007200phospholipase C-activating G-protein coupled recepIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0015056corticotrophin-releasing factor receptor activityIEAmolecular_function
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0042755eating behaviorIEAbiological_process
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0007190activation of adenylate cyclase activityTASbiological_process
GO:0031982vesicleIEAcellular_component
GO:0048266behavioral response to painIEAbiological_process
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0042277peptide bindingIEAmolecular_function
GO:0030425dendriteIEAcellular_component
GO:0007613memoryIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function