| UniProt/SwissProt ID: | CALCR_HUMAN |
| Description: | calcitonin receptor [Source:HGNC Symbol;Acc:1440] |
| Location: | chr7 q21.3 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y56 | AQYKCyDRMQQ | PhosphoSitePlus | |
| Y41 | PKPFLyVVGRK | PhosphoSitePlus | |
| T132 | TWSNYtMCNAF | HRM | PhosphoSitePlus |
| Y131 | RTWSNyTMCNA | HRM | PhosphoSitePlus |
| Y53 | MMDAQyKCYDR | PhosphoSitePlus | |
| S234 | RRDPVsCKILH | 7tm_2 | PhosphoSitePlus |
| T138 | MCNAFtPEKLK | PhosphoSitePlus | |
| T178 | FRKLTtIFPLN | PhosphoSitePlus | |
| Dephosphorylation site |
| CALCR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CALCR_HUMAN do not have mutation site. |
| Differential expressed protein |
| CALCR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CALCR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IAPP_HUMAN | CALCR_HUMAN | ligand -> receptor | HPMR |
| CALC_HUMAN | CALCR_HUMAN | ligand -> receptor | HPMR |
| CALCB_HUMAN | CALCR_HUMAN | ligand -> receptor | HPMR |
| CALCR_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| CALCR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| CALCR_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| CALCR_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04380 | Osteoclast differentiation |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015031 | protein transport | IDA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0031623 | receptor internalization | IDA | biological_process |
| GO:0072659 | protein localization to plasma membrane | IDA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051384 | response to glucocorticoid stimulus | IDA | biological_process |
| GO:0045762 | positive regulation of adenylate cyclase activity | IDA | biological_process |
| GO:0005887 | integral to plasma membrane | NAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | NAS | biological_process |
| GO:0004948 | calcitonin receptor activity | IEA | molecular_function |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IDA | biological_process |
| GO:0032841 | calcitonin binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0008565 | protein transporter activity | IDA | molecular_function |
| GO:0004872 | receptor activity | IDA | molecular_function |
| GO:0030819 | positive regulation of cAMP biosynthetic process | IDA | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | IEA | molecular_function |