Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY9_HUMAN
Description:adenylate cyclase 9 [Source:HGNC Symbol;Acc:240]
Location:chr16 p13.3
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S357EESENsVKRHAPhosphoSitePlus; HPRD; phosphoELM
T494GVHTGtVLCGIGuanylate_cycPhosphoSitePlus
S364KRHATsSPKNRPhosphoSitePlus
S39PKQLSsNSHPKPhosphoSitePlus
Y1225GYDFDyRGTVNGuanylate_cycPhosphoSitePlus
Y122RYALFyIGFACTMPhosphoSitePlus
T363VKRHAtSSPKNPhosphoSitePlus
S365RHATSsPKNRKPhosphoSitePlus; HPRD; SysPTM
Y1221LSKMGyDFDYRGuanylate_cycPhosphoSitePlus
S1259HQLSIsPDIRVPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S56SSSCSsSGDSGPhosphoSitePlus
Y133LLWSIyFAVHMTMPhosphoSitePlus
S1257PQHQLsISPDIPhosphoSitePlus; HPRD
S354QGDEEsENSVKPhosphoSitePlus; HPRD; phosphoELM
S1307KDAHLsPKRPWPhosphoSitePlus; HPRD
T1109IEKIKtIGATYGuanylate_cycPhosphoSitePlus
S38NPKQLsSNSHPPhosphoSitePlus
Y172LYARHyAWTSLTMPhosphoSitePlus
S25DSSGDsNSVRVPhosphoSitePlus

Dephosphorylation site
ADCY9_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000294016C583FCOSMICOvarian Cancer21720365
ENSP00000294016E1314KBIOMARTBreast Cancer21930507, 21930502
ENSP00000294016R1310SCOSMICOvarian Cancer21720365
ENSP00000294016S900LCOSMICIntestines Cancer17932254
ENSP00000294016M1197VCOSMICOvarian Cancer21720365
ENSP00000294016V157LCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000294016Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ADCY9_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS2_HUMANADCY9_HUMANGprotein -> effectorgpDB
GNAS1_HUMANADCY9_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04972Pancreatic secretion
hsa04540Gap junction
hsa00230Purine metabolism
hsa04976Bile secretion
hsa04916Melanogenesis
hsa04270Vascular smooth muscle contraction
hsa05414Dilated cardiomyopathy
hsa05166HTLV-I infection
hsa05110Vibrio cholerae infection
hsa04970Salivary secretion
hsa04727GABAergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05032Morphine addiction
hsa04912GnRH signaling pathway
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04020Calcium signaling pathway
hsa04062Chemokine signaling pathway
hsa04962Vasopressin-regulated water reabsorption
hsa04914Progesterone-mediated oocyte maturation
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04114Oocyte meiosis
hsa04971Gastric acid secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0006171cAMP biosynthetic processIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0004016adenylate cyclase activityIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0006833water transportTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process


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