Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EDNRA_HUMAN
Description:endothelin receptor type A [Source:HGNC Symbol;Acc:3179]
Location:chr4 q31.22
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T403VPMNGtSIQWKPhosphoSitePlus
S391CCCYQsKSLMTPhosphoSitePlus
S295LRIALsEHLKQ7tm_1PhosphoSitePlus
Y275CTAIFyTLMTC7tm_1; TMPhosphoSitePlus
S382KNCFQsCLCCCPhosphoSitePlus
S397KSLMTsVPMNGPhosphoSitePlus
S289NRRNGsLRIAL7tm_1PhosphoSitePlus
S404PMNGTsIQWKNPhosphoSitePlus
S420HNTDRsSHKDSPhosphoSitePlus
S425SSHKDsMN___PhosphoSitePlus
S393CYQSKsLMTSVPhosphoSitePlus
Y389LCCCCyQSKSLPhosphoSitePlus
T417QNNHNtDRSSHPhosphoSitePlus
Y184LSVDRyRAVAS7tm_1PhosphoSitePlus
Y263WLFGFyFCMPL7tm_1; TMPhosphoSitePlus
T396SKSLMtSVPMNPhosphoSitePlus
Y333LKKTVyNEMDK7tm_1PhosphoSitePlus
S421NTDRSsHKDSMPhosphoSitePlus

Dephosphorylation site
EDNRA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000315011R145CBIOMARTBreast Cancer21930507, 21930502
ENSP00000315011H150YBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000351359R41HTCGAOvarian Cancer21720365, 18772890
ENSP00000315011R41HCOSMICOvarian Cancer21720365
ENSP00000315011I136LSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000425281R41HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
EDNRA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EDNRA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EDN1_HUMANEDNRA_HUMANligand -> receptorHPMR
EDN2_HUMANEDNRA_HUMANligand -> receptorHPMR
EDNRA_HUMANGNAQ_HUMANGPCR -> GproteingpDB
EDNRA_HUMANGNAS2_HUMANGPCR -> GproteingpDB
EDNRA_HUMANGNA12_HUMANGPCR -> GproteingpDB
EDNRA_HUMANGNA13_HUMANGPCR -> GproteingpDB
EDNRA_HUMANGNAS1_HUMANGPCR -> GproteingpDB
EDNRA_HUMANGNA11_HUMANGPCR -> GproteingpDB
IP3KA_HUMANEDNRA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
hsa04270Vascular smooth muscle contraction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051482elevation of cytosolic calcium ion concentration iIEAbiological_process
GO:0090023positive regulation of neutrophil chemotaxisIEAbiological_process
GO:0060322head developmentIEAbiological_process
GO:0060137maternal process involved in parturitionIEAbiological_process
GO:0004962endothelin receptor activityNASmolecular_function
GO:0014824artery smooth muscle contractionIMPbiological_process
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0048144fibroblast proliferationIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0090184positive regulation of kidney developmentIEAbiological_process
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0031965nuclear membraneIEAcellular_component
GO:0030315T-tubuleIEAcellular_component
GO:0007585respiratory gaseous exchangeIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048659smooth muscle cell proliferationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0030818negative regulation of cAMP biosynthetic processIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0042482positive regulation of odontogenesisIEAbiological_process
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0042310vasoconstrictionIMPbiological_process
GO:0003094glomerular filtrationIEAbiological_process
GO:0051281positive regulation of release of sequestered calcIEAbiological_process
GO:0043278response to morphineIEAbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0019233sensory perception of painIEAbiological_process
GO:0008283cell proliferationNASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayNASbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0007585respiratory gaseous exchangeISSbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0042310vasoconstrictionIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0086100endothelin receptor signaling pathwayIEAbiological_process
GO:0001821histamine secretionIEAbiological_process
GO:0004962endothelin receptor activityIEAmolecular_function
GO:0007205protein kinase C-activating G-protein coupled receIEAbiological_process
GO:0051928positive regulation of calcium ion transportIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0015758glucose transportISSbiological_process
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0043084penile erectionIEAbiological_process
GO:0015758glucose transportIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0016020membraneNAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0014032neural crest cell developmentIEAbiological_process
GO:0007190activation of adenylate cyclase activityTASbiological_process
GO:0006939smooth muscle contractionNASbiological_process