Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GHRHR_HUMAN
Description:growth hormone releasing hormone receptor [Source:HGNC Symbol;Acc:4266]
Location:chr7 p14.3
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
GHRHR_HUMAN do not have phosphorylation site.

Dephosphorylation site
GHRHR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000320180N216TCOSMICOvarian Cancer21720365
ENSP00000320180A45TSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000320180H210NCOSMICHead and Neck Cancer21798893
ENSP00000320180A45THPIColorectal Cancer16959974
ENSP00000320180N216TTCGAOvarian Cancer21720365, 18772890
ENSP00000320180I344MCOSMICHead and Neck Cancer21798893

Differential expressed protein
GHRHR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GHRHR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SLIB_HUMANGHRHR_HUMANligand -> receptorHPMR
GHRHR_HUMANGNAS1_HUMANGPCR -> GproteingpDB
GHRHR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
GLHA_HUMANGHRHR_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060124positive regulation of growth hormone secretionNASbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0043567regulation of insulin-like growth factor receptor IEAbiological_process
GO:0017046peptide hormone bindingIEAmolecular_function
GO:0007189adenylate cyclase-activating G-protein coupled recIDAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0004930G-protein coupled receptor activityICmolecular_function
GO:0016520growth hormone-releasing hormone receptor activityIEAmolecular_function
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0043627response to estrogen stimulusIDAbiological_process
GO:0043568positive regulation of insulin-like growth factor NASbiological_process
GO:0051246regulation of protein metabolic processIEAbiological_process
GO:0060133somatotropin secreting cell developmentIEAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0030104water homeostasisIEAbiological_process
GO:0040018positive regulation of multicellular organism growIMPbiological_process
GO:0060124positive regulation of growth hormone secretionIEAbiological_process
GO:0042445hormone metabolic processIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0046887positive regulation of hormone secretionIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005637nuclear inner membraneIDAcellular_component
GO:0007595lactationIEAbiological_process
GO:0016363nuclear matrixIDAcellular_component
GO:0030816positive regulation of cAMP metabolic processIEAbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0005640nuclear outer membraneIDAcellular_component
GO:0008340determination of adult lifespanIEAbiological_process
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0048609multicellular organismal reproductive processNASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0021984adenohypophysis developmentIEAbiological_process
GO:0007190activation of adenylate cyclase activityIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0019838growth factor bindingIPImolecular_function
GO:0019933cAMP-mediated signalingIMPbiological_process
GO:0033143regulation of intracellular steroid hormone receptIEAbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recIEAbiological_process
GO:0032868response to insulin stimulusIMPbiological_process
GO:0051384response to glucocorticoid stimulusIDAbiological_process
GO:0016021integral to membraneIDAcellular_component
GO:0030141secretory granuleIDAcellular_component
GO:0017046peptide hormone bindingIPImolecular_function
GO:0030252growth hormone secretionIEAbiological_process
GO:0048469cell maturationIEAbiological_process
GO:0016520growth hormone-releasing hormone receptor activityIMPmolecular_function