Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DRD1_HUMAN
Description:dopamine receptor D1 [Source:HGNC Symbol;Acc:3020]
Location:chr5 q35.2
Node attribute:PPI(target); GPCR; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T360NNAIEtVSINNPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
DRD1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000327652L76MCOSMICOvarian Cancer21720365
ENSP00000327652I438TCOSMICOvarian Cancer21720365
ENSP00000327652V430ICOSMICHead and Neck Cancer21798893
ENSP00000327652W318*COSMICSkin Cancer21984974

Differential expressed protein
DRD1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DRD1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TY3H_HUMANDRD1_HUMANligand -> receptorHPMR
DRD1_HUMANGNAS1_HUMANGPCR -> GproteingpDB
DRD1_HUMANGNAS2_HUMANGPCR -> GproteingpDB
IP3KA_HUMANDRD1_HUMANotherKEGG
MEIS2_HUMANDRD1_HUMANTF -> target geneTRANSFAC
TGIF1_HUMANDRD1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa04080Neuroactive ligand-receptor interaction
hsa04728Dopaminergic synapse
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa04020Calcium signaling pathway
hsa05032Morphine addiction
hsa05030Cocaine addiction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008542visual learningISSbiological_process
GO:0007617mating behaviorISSbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0007212dopamine receptor signaling pathwayIEAbiological_process
GO:0007610behaviorIEAbiological_process
GO:0001661conditioned taste aversionIEAbiological_process
GO:0042417dopamine metabolic processICbiological_process
GO:0030335positive regulation of cell migrationISSbiological_process
GO:0006606protein import into nucleusIEAbiological_process
GO:0035106operant conditioningIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0071870cellular response to catecholamine stimulusIDAbiological_process
GO:0060292long term synaptic depressionIEAbiological_process
GO:0007191adenylate cyclase-activating dopamine receptor sigIDAbiological_process
GO:0021766hippocampus developmentIEAbiological_process
GO:0007612learningIEAbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupIDAbiological_process
GO:0007190activation of adenylate cyclase activityIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007628adult walking behaviorISSbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007625grooming behaviorIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007626locomotory behaviorIEAbiological_process
GO:0042220response to cocaineIEAbiological_process
GO:0006936muscle contractionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007416synapse assemblyISSbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recIDAbiological_process
GO:0015872dopamine transportIEAbiological_process
GO:0007617mating behaviorIEAbiological_process
GO:0051968positive regulation of synaptic transmission, glutIEAbiological_process
GO:0001588dopamine neurotransmitter receptor activity, couplIMPmolecular_function
GO:0007191adenylate cyclase-activating dopamine receptor sigIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007631feeding behaviorIEAbiological_process
GO:0001659temperature homeostasisIEAbiological_process
GO:0042053regulation of dopamine metabolic processIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0008542visual learningIEAbiological_process
GO:0014002astrocyte developmentIEAbiological_process
GO:0021853cerebral cortex GABAergic interneuron migrationISSbiological_process
GO:0042493response to drugIEAbiological_process
GO:0007613memoryIEAbiological_process
GO:0051482elevation of cytosolic calcium ion concentration iIDAbiological_process
GO:0035240dopamine bindingIMPmolecular_function
GO:0001975response to amphetamineIEAbiological_process
GO:0019226transmission of nerve impulseIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0004952dopamine neurotransmitter receptor activityIDAmolecular_function
GO:0042493response to drugISSbiological_process
GO:0060158phospholipase C-activating dopamine receptor signaIDAbiological_process
GO:0030432peristalsisIEAbiological_process
GO:0043268positive regulation of potassium ion transportISSbiological_process
GO:0046960sensitizationIEAbiological_process
GO:0021756striatum developmentIEAbiological_process
GO:0060158phospholipase C-activating dopamine receptor signaIEAbiological_process
GO:0048148behavioral response to cocaineIEAbiological_process
GO:0007190activation of adenylate cyclase activityIEAbiological_process
GO:0046323glucose importIEAbiological_process
GO:0005887integral to plasma membraneICcellular_component
GO:0021542dentate gyrus developmentIEAbiological_process
GO:0004952dopamine neurotransmitter receptor activityIEAmolecular_function
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0001662behavioral fear responseIEAbiological_process
GO:0051584regulation of dopamine uptake involved in synapticICbiological_process
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0051281positive regulation of release of sequestered calcIDAbiological_process
GO:0008306associative learningIEAbiological_process
GO:0051968positive regulation of synaptic transmission, glutISSbiological_process
GO:0001588dopamine neurotransmitter receptor activity, couplIEAmolecular_function
GO:0021853cerebral cortex GABAergic interneuron migrationIEAbiological_process
GO:0019226transmission of nerve impulseISSbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0060134prepulse inhibitionISSbiological_process
GO:0019228regulation of action potential in neuronIEAbiological_process
GO:0007628adult walking behaviorIEAbiological_process