Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY3_HUMAN
Description:adenylate cyclase 3 [Source:HGNC Symbol;Acc:234]
Location:chr2 p23.3
Node attribute:effector; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T417RVGVHtGTVLGGuanylate_cycPhosphoSitePlus
S1076ASRMEsTGVMGphosphoELM
T419GVHTGtVLGGVGuanylate_cycPhosphoSitePlus
T407REKTKtGVDMRGuanylate_cycPhosphoSitePlus
S580RVVDAsEDEHEHPRD
S1076ASRMEsTGVMGCAMK2GHPRD
S857SFYYFsRHVEKPhosphoSitePlus
S1076ASRMEsTGVMGCaMK2gRegPhos
Y854MMLSFyYFSRHPhosphoSitePlus
S1076ASRMEsTGVMGCaMK2_groupRegPhos
T701TWIDRtRWARNPhosphoSitePlus
S1076ASRMEsTGVMGCaM-KII_groupphosphoELM
Y12FSEPEySAEYSPhosphoSitePlus

Dephosphorylation site
ADCY3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260600P25SCOSMICOvarian Cancer21720365
ENSP00000260600Y730*COSMICOvarian Cancer21720365

Differential expressed protein
ADCY3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADCY3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS1_HUMANADCY3_HUMANGprotein -> effectorgpDB
GNAS2_HUMANADCY3_HUMANGprotein -> effectorgpDB
KCC4_HUMANADCY3_HUMANkinase -> substrateRobert H Newman (2013)
KCC2G_HUMANADCY3_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04972Pancreatic secretion
hsa05032Morphine addiction
hsa04971Gastric acid secretion
hsa04740Olfactory transduction
hsa05414Dilated cardiomyopathy
hsa04062Chemokine signaling pathway
hsa04970Salivary secretion
hsa04962Vasopressin-regulated water reabsorption
hsa00230Purine metabolism
hsa04725Cholinergic synapse
hsa04114Oocyte meiosis
hsa04727GABAergic synapse
hsa04976Bile secretion
hsa04020Calcium signaling pathway
hsa05166HTLV-I infection
hsa05110Vibrio cholerae infection
hsa04270Vascular smooth muscle contraction
hsa04914Progesterone-mediated oocyte maturation
hsa04723Retrograde endocannabinoid signaling
hsa04540Gap junction
hsa04912GnRH signaling pathway
hsa04916Melanogenesis
hsa04724Glutamatergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneTAScellular_component
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0006833water transportTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007608sensory perception of smellIEAbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0004016adenylate cyclase activityIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0006112energy reserve metabolic processTASbiological_process
GO:0055085transmembrane transportTASbiological_process


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