| UniProt/SwissProt ID: | NK3R_HUMAN |
| Description: | tachykinin receptor 3 [Source:HGNC Symbol;Acc:11528] |
| Location: | chr4 q24 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T410 | RMESMtVVFDP | PhosphoSitePlus | |
| T404 | SMYTVtRMESM | PhosphoSitePlus | |
| Dephosphorylation site |
| NK3R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000303325 | D417N | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000303325 | A128T | COSMIC | Lung Cancer | 20668451 | ENSP00000303325 | N138D | COSMIC | Breast Cancer | 20668451 | ENSP00000303325 | A180V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000303325 | K368N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000303325 | M409I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000303325 | S451* | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| NK3R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NK3R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TKNK_HUMAN | NK3R_HUMAN | ligand -> receptor | HPMR |
| TKN1_HUMAN | NK3R_HUMAN | ligand -> receptor | HPMR |
| NK3R_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| NK3R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| NK3R_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| NK3R_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| IP3KA_HUMAN | NK3R_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0010460 | positive regulation of heart rate | IEA | biological_process |
| GO:0060259 | regulation of feeding behavior | IEA | biological_process |
| GO:0070474 | positive regulation of uterine smooth muscle contr | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0042538 | hyperosmotic salinity response | IEA | biological_process |
| GO:0042053 | regulation of dopamine metabolic process | IEA | biological_process |
| GO:0007568 | aging | IEA | biological_process |
| GO:0045777 | positive regulation of blood pressure | IEA | biological_process |
| GO:0043278 | response to morphine | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007217 | tachykinin receptor signaling pathway | IEA | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0042220 | response to cocaine | IEA | biological_process |
| GO:0004995 | tachykinin receptor activity | IEA | molecular_function |
| GO:0032355 | response to estradiol stimulus | IEA | biological_process |
| GO:0007217 | tachykinin receptor signaling pathway | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |