| UniProt/SwissProt ID: | PE2R2_HUMAN |
| Description: | prostaglandin E receptor 2 (subtype EP2), 53kDa [Source:HGNC Symbol;Acc:9594] |
| Location: | chr14 q22.1 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S33 | SSVMFsAGVLG | TM | PhosphoSitePlus |
| S57 | GDVGCsAGRRS | 7tm_1 | PhosphoSitePlus |
| T15 | SEDCEtRQWLP | PhosphoSitePlus | |
| T194 | IRHGRtAYLQL | 7tm_1 | PhosphoSitePlus |
| S62 | SAGRRsSLSLF | 7tm_1 | PhosphoSitePlus |
| S10 | SNDSQsEDCET | PhosphoSitePlus | |
| Y196 | HGRTAyLQLYA | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| PE2R2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000245457 | R95L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000245457 | W313* | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 | ENSP00000245457 | L358F | COSMIC | Lung Cancer | 20668451 | ENSP00000245457 | Q299* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| PE2R2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PE2R2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PE2R2_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| PE2R2_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042127 | regulation of cell proliferation | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0032496 | response to lipopolysaccharide | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0071380 | cellular response to prostaglandin E stimulus | IEA | biological_process |
| GO:0004957 | prostaglandin E receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | IEA | biological_process |