| UniProt/SwissProt ID: | GLP1R_HUMAN |
| Description: | glucagon-like peptide 1 receptor [Source:HGNC Symbol;Acc:4324] |
| Location: | chr6 p21.2 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| GLP1R_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| GLP1R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362353 | E68G | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000362353 | Q428R | COSMIC | Breast Cancer | 20668451 | ENSP00000362353 | S432R | COSMIC | Lung Cancer | ENSP00000362353 | A399D | COSMIC | Lung Cancer | 20668451 | ENSP00000362353 | V325L | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| GLP1R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GLP1R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GLUC_HUMAN | GLP1R_HUMAN | ligand -> receptor | HPMR |
| GLP1R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| GLP1R_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | GLP1R_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050796 | regulation of insulin secretion | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0008528 | G-protein coupled peptide receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007204 | elevation of cytosolic calcium ion concentration | IDA | biological_process |
| GO:0007190 | activation of adenylate cyclase activity | TAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0004967 | glucagon receptor activity | IEA | molecular_function |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0019933 | cAMP-mediated signaling | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |