| UniProt/SwissProt ID: | ADCY8_HUMAN |
| Description: | adenylate cyclase 8 (brain) [Source:HGNC Symbol;Acc:239] |
| Location: | chr8 q24.22 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S692 | HIKPFsLMFKD | DUF1053 | PhosphoSitePlus |
| S1159 | YVKGIsEQEGK | HPRD; phosphoELM | |
| Y1154 | YRGEIyVKGIS | Guanylate_cyc | PhosphoSitePlus |
| S1159 | YVKGIsEQEGK | Guanylate_cyc | PhosphoSitePlus |
| Y406 | QFHRIyIHRYE | Guanylate_cyc | PhosphoSitePlus |
| S4 | __MELsDVRCL | PhosphoSitePlus | |
| Y410 | IYIHRyENVSI | Guanylate_cyc | PhosphoSitePlus |
| Dephosphorylation site |
| ADCY8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000286355 | R457S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000286355 | G513D | COSMIC | Skin Cancer | 21984974 | ENSP00000286355 | R172H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000286355 | P734L | COSMIC | Skin Cancer | 21984974 | ENSP00000286355 | R924G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000286355 | R772Q | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000286355 | D681N | COSMIC | Melanoma | 21499247 | ENSP00000286355 | Q256* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000286355 | L175F | COSMIC | Skin Cancer | 21984974 | ENSP00000286355 | S746F | COSMIC | Skin Cancer | 21984974 | ENSP00000286355 | H403Y | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000286355 | R344W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000286355 | S342L | COSMIC | Skin Cancer | 21984974 | ENSP00000286355 | F881L | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 | ENSP00000286355 | G1239E | COSMIC | Central Nervous System Neoplasms | 21817013 | ENSP00000286355 | E666K | COSMIC | Melanoma | 21499247 | ENSP00000286355 | F881L | HPI | Colorectal Cancer | 16959974 |
| Differential expressed protein |
| ADCY8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ADCY8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAS2_HUMAN | ADCY8_HUMAN | Gprotein -> effector | gpDB |
| GNAS1_HUMAN | ADCY8_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04062 | Chemokine signaling pathway |
| hsa04970 | Salivary secretion |
| hsa04270 | Vascular smooth muscle contraction |
| hsa05032 | Morphine addiction |
| hsa04020 | Calcium signaling pathway |
| hsa04114 | Oocyte meiosis |
| hsa05414 | Dilated cardiomyopathy |
| hsa04916 | Melanogenesis |
| hsa04972 | Pancreatic secretion |
| hsa04912 | GnRH signaling pathway |
| hsa04720 | Long-term potentiation |
| hsa04724 | Glutamatergic synapse |
| hsa04976 | Bile secretion |
| hsa05166 | HTLV-I infection |
| hsa04540 | Gap junction |
| hsa04742 | Taste transduction |
| hsa00230 | Purine metabolism |
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa04723 | Retrograde endocannabinoid signaling |
| hsa04971 | Gastric acid secretion |
| hsa04727 | GABAergic synapse |
| hsa04725 | Cholinergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | TAS | cellular_component |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0007611 | learning or memory | TAS | biological_process |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0007189 | adenylate cyclase-activating G-protein coupled rec | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0009190 | cyclic nucleotide biosynthetic process | IEA | biological_process |
| GO:0004016 | adenylate cyclase activity | IEA | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0048011 | nerve growth factor receptor signaling pathway | TAS | biological_process |
| GO:0006833 | water transport | TAS | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0007193 | adenylate cyclase-inhibiting G-protein coupled rec | TAS | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0071377 | cellular response to glucagon stimulus | TAS | biological_process |
| GO:0016849 | phosphorus-oxygen lyase activity | IEA | molecular_function |
| GO:0007202 | activation of phospholipase C activity | TAS | biological_process |
| GO:0007616 | long-term memory | IEA | biological_process |
| GO:0034199 | activation of protein kinase A activity | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0008294 | calcium- and calmodulin-responsive adenylate cycla | TAS | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |