Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADCY8_HUMAN
Description:adenylate cyclase 8 (brain) [Source:HGNC Symbol;Acc:239]
Location:chr8 q24.22
Node attribute:effector

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S692HIKPFsLMFKDDUF1053PhosphoSitePlus
S1159YVKGIsEQEGKHPRD; phosphoELM
Y1154YRGEIyVKGISGuanylate_cycPhosphoSitePlus
S1159YVKGIsEQEGKGuanylate_cycPhosphoSitePlus
Y406QFHRIyIHRYEGuanylate_cycPhosphoSitePlus
S4__MELsDVRCLPhosphoSitePlus
Y410IYIHRyENVSIGuanylate_cycPhosphoSitePlus

Dephosphorylation site
ADCY8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000286355R457SBIOMARTBreast Cancer21930507, 21930502
ENSP00000286355G513DCOSMICSkin Cancer21984974
ENSP00000286355R172HCOSMICHead and Neck Cancer21798893
ENSP00000286355P734LCOSMICSkin Cancer21984974
ENSP00000286355R924GCOSMICHead and Neck Cancer21798893
ENSP00000286355R772QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000286355D681NCOSMICMelanoma21499247
ENSP00000286355Q256*COSMICHead and Neck Cancer21798893
ENSP00000286355L175FCOSMICSkin Cancer21984974
ENSP00000286355S746FCOSMICSkin Cancer21984974
ENSP00000286355H403YCOSMICHead and Neck Cancer21984974
ENSP00000286355R344WCOSMICHead and Neck Cancer21798893
ENSP00000286355S342LCOSMICSkin Cancer21984974
ENSP00000286355F881LSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000286355G1239ECOSMICCentral Nervous System Neoplasms21817013
ENSP00000286355E666KCOSMICMelanoma21499247
ENSP00000286355F881LHPIColorectal Cancer16959974

Differential expressed protein
ADCY8_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADCY8_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAS2_HUMANADCY8_HUMANGprotein -> effectorgpDB
GNAS1_HUMANADCY8_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa04970Salivary secretion
hsa04270Vascular smooth muscle contraction
hsa05032Morphine addiction
hsa04020Calcium signaling pathway
hsa04114Oocyte meiosis
hsa05414Dilated cardiomyopathy
hsa04916Melanogenesis
hsa04972Pancreatic secretion
hsa04912GnRH signaling pathway
hsa04720Long-term potentiation
hsa04724Glutamatergic synapse
hsa04976Bile secretion
hsa05166HTLV-I infection
hsa04540Gap junction
hsa04742Taste transduction
hsa00230Purine metabolism
hsa04914Progesterone-mediated oocyte maturation
hsa04723Retrograde endocannabinoid signaling
hsa04971Gastric acid secretion
hsa04727GABAergic synapse
hsa04725Cholinergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneTAScellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0007611learning or memoryTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0009190cyclic nucleotide biosynthetic processIEAbiological_process
GO:0004016adenylate cyclase activityIEAmolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0006833water transportTASbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0007193adenylate cyclase-inhibiting G-protein coupled recTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0071377cellular response to glucagon stimulusTASbiological_process
GO:0016849phosphorus-oxygen lyase activityIEAmolecular_function
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0007616long-term memoryIEAbiological_process
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0008294calcium- and calmodulin-responsive adenylate cyclaTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process


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