Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTH2R_HUMAN
Description:parathyroid hormone 2 receptor [Source:HGNC Symbol;Acc:9609]
Location:chr2 q34
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S18WLMLGsCLLARPhosphoSitePlus
T354AVGHDtRKQYR7tm_2PhosphoSitePlus
T546GCQGEtEDVL_PhosphoSitePlus
T546GCQGEtEDHPRD
S445TPPCGsRRCGSPhosphoSitePlus

Dephosphorylation site
PTH2R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000272847E527QTCGAOvarian Cancer21720365, 18772890
ENSP00000272847E527QCOSMICOvarian Cancer21720365
ENSP00000272847D132HCOSMICBreast Cancer20668451
ENSP00000272847R446HCOSMICSkin Cancer21984974
ENSP00000272847D124NCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000272847Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3215169874

Hyperphosphorylation site
PTH2R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TIP39_HUMANPTH2R_HUMANligand -> receptorHPMR
PTHY_HUMANPTH2R_HUMANligand -> receptorHPMR
PTH2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
PTH2R_HUMANGNAS1_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0004991parathyroid hormone receptor activityTASmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneTAScellular_component


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