Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADRB1_HUMAN
Description:adrenoceptor beta 1 [Source:HGNC Symbol;Acc:285]
Location:chr10 q25.3
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y210EARRCyNDPKC7tm_1PhosphoSitePlus
S312GKRRPsRLVAL7tm_1PhosphoSitePlus

Dephosphorylation site
ADRB1_HUMAN do not have dephosphorylation site.

Mutation site
ADRB1_HUMAN do not have mutation site.

Differential expressed protein
ADRB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADRB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DOPO_HUMANADRB1_HUMANligand -> receptorHPMR
ADRB1_HUMANGNAS1_HUMANGPCR -> GproteingpDB
ADRB1_HUMANGNAS2_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa05414Dilated cardiomyopathy
hsa04970Salivary secretion
hsa04144Endocytosis
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031649heat generationIEAbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0051924regulation of calcium ion transportIEAbiological_process
GO:0002024diet induced thermogenesisIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0001997positive regulation of the force of heart contractIEAbiological_process
GO:0045986negative regulation of smooth muscle contractionIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0001996positive regulation of heart rate by epinephrine-nIEAbiological_process
GO:0007613memoryIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0061051positive regulation of cell growth involved in carIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0050873brown fat cell differentiationIEAbiological_process
GO:0003061positive regulation of the force of heart contractIEAbiological_process
GO:0040015negative regulation of multicellular organism growIEAbiological_process
GO:0042060wound healingIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0031694alpha-2A adrenergic receptor bindingIPImolecular_function
GO:0051380norepinephrine bindingIEAmolecular_function
GO:0007190activation of adenylate cyclase activityTASbiological_process
GO:0004940beta1-adrenergic receptor activityIEAmolecular_function
GO:0019233sensory perception of painIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIEAbiological_process
GO:0008144drug bindingIEAmolecular_function
GO:0007568agingIEAbiological_process
GO:0046878positive regulation of saliva secretionIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0003084positive regulation of systemic arterial blood preIEAbiological_process
GO:0035811negative regulation of urine volumeIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0002025vasodilation by norepinephrine-epinephrine involveIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0004939beta-adrenergic receptor activityTASmolecular_function
GO:0086004regulation of cardiac muscle cell contractionIEAbiological_process
GO:0035240dopamine bindingIEAmolecular_function
GO:0060080regulation of inhibitory postsynaptic membrane potIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0055088lipid homeostasisIEAbiological_process
GO:0033365protein localization to organelleIEAbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recIEAbiological_process
GO:0010460positive regulation of heart rateIEAbiological_process
GO:2001259positive regulation of cation channel activityIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0030165PDZ domain bindingIPImolecular_function
GO:0051379epinephrine bindingIEAmolecular_function
GO:0009409response to coldIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0042596fear responseIEAbiological_process
GO:0005980glycogen catabolic processIEAbiological_process