Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NK2R_HUMAN
Description:tachykinin receptor 2 [Source:HGNC Symbol;Acc:11527]
Location:chr10 q22.1
Node attribute:GPCR; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T339DKLELtPTTSLPhosphoSitePlus

Dephosphorylation site
NK2R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000362403R103CCOSMICHead and Neck Cancer21984974
ENSP00000362403A145TCOSMICProstate Cancer20668451
ENSP00000362403D278YCOSMICOvarian Cancer21720365
ENSP00000362403G2ACOSMICOvarian Cancer21720365

Differential expressed protein
NK2R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NK2R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TKNK_HUMANNK2R_HUMANligand -> receptorHPMR
TKN1_HUMANNK2R_HUMANligand -> receptorHPMR
NK2R_HUMANGNAS1_HUMANGPCR -> GproteingpDB
NK2R_HUMANGNAQ_HUMANGPCR -> GproteingpDB
NK2R_HUMANGNA11_HUMANGPCR -> GproteingpDB
NK2R_HUMANGNAS2_HUMANGPCR -> GproteingpDB
IP3KA_HUMANNK2R_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007588excretionTASbiological_process
GO:0033685negative regulation of luteinizing hormone secretiIEAbiological_process
GO:0043117positive regulation of vascular permeabilityIEAbiological_process
GO:0043270positive regulation of ion transportIEAbiological_process
GO:0004995tachykinin receptor activityTASmolecular_function
GO:0006936muscle contractionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0016497substance K receptor activityIEAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0070474positive regulation of uterine smooth muscle contrIEAbiological_process
GO:0007217tachykinin receptor signaling pathwayTASbiological_process
GO:0035106operant conditioningIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0070459prolactin secretionIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0014057positive regulation of acetylcholine secretionIEAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0014827intestine smooth muscle contractionIEAbiological_process


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