| UniProt/SwissProt ID: | NK2R_HUMAN |
| Description: | tachykinin receptor 2 [Source:HGNC Symbol;Acc:11527] |
| Location: | chr10 q22.1 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T339 | DKLELtPTTSL | PhosphoSitePlus | |
| Dephosphorylation site |
| NK2R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362403 | R103C | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000362403 | A145T | COSMIC | Prostate Cancer | 20668451 | ENSP00000362403 | D278Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362403 | G2A | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| NK2R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NK2R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TKNK_HUMAN | NK2R_HUMAN | ligand -> receptor | HPMR |
| TKN1_HUMAN | NK2R_HUMAN | ligand -> receptor | HPMR |
| NK2R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| NK2R_HUMAN | GNAQ_HUMAN | GPCR -> Gprotein | gpDB |
| NK2R_HUMAN | GNA11_HUMAN | GPCR -> Gprotein | gpDB |
| NK2R_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| IP3KA_HUMAN | NK2R_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007588 | excretion | TAS | biological_process |
| GO:0033685 | negative regulation of luteinizing hormone secreti | IEA | biological_process |
| GO:0043117 | positive regulation of vascular permeability | IEA | biological_process |
| GO:0043270 | positive regulation of ion transport | IEA | biological_process |
| GO:0004995 | tachykinin receptor activity | TAS | molecular_function |
| GO:0006936 | muscle contraction | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0016497 | substance K receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0070474 | positive regulation of uterine smooth muscle contr | IEA | biological_process |
| GO:0007217 | tachykinin receptor signaling pathway | TAS | biological_process |
| GO:0035106 | operant conditioning | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0070459 | prolactin secretion | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0014057 | positive regulation of acetylcholine secretion | IEA | biological_process |
| GO:0006950 | response to stress | IEA | biological_process |
| GO:0014827 | intestine smooth muscle contraction | IEA | biological_process |