| UniProt/SwissProt ID: | TAAR6_HUMAN |
| Description: | trace amine associated receptor 6 [Source:HGNC Symbol;Acc:20978] |
| Location: | chr6 q23.2 |
| Node attribute: | GPCR |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S244 | ESSSEsYKARV | 7tm_1 | PhosphoSitePlus |
| T238 | NTGSKtESSSE | 7tm_1 | PhosphoSitePlus |
| Y245 | SSSESyKARVA | 7tm_1 | PhosphoSitePlus |
| S241 | SKTESsSESYK | 7tm_1 | PhosphoSitePlus |
| Y140 | TDPLVyPTKFT | 7tm_1 | PhosphoSitePlus |
| Y131 | ISIDRyIAVTD | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| TAAR6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000275198 | Q62K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000275198 | C116F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000275198 | K258N | BIOMART | chronic lymphocytic leukemia | 21930507, 21930502 | ENSP00000275198 | R254I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000275198 | R254I | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| TAAR6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TAAR6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TAAR6_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| TAAR6_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0001594 | trace-amine receptor activity | IEA | molecular_function |