Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACTHR_HUMAN
Description:melanocortin 2 receptor (adrenocorticotropic hormone) [Source:HGNC Symbol;Acc:6930]
Location:chr18 p11.21
Node attribute:PPI(target); GPCR; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T143YHSIVtMRRTV7tm_1PhosphoSitePlus
S280IYAFRsPELRDPhosphoSitePlus
S208HTRKIsTLPRA7tm_1PhosphoSitePlus

Dephosphorylation site
ACTHR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000382718R279WCOSMICOvarian Cancer21720365
ENSP00000382718A135TCOSMICHead and Neck Cancer21798893
ENSP00000382718S180LCOSMICOvarian Cancer21720365
ENSP00000382718E99KCOSMICMelanoma21499247
ENSP00000382718L66MCOSMICOvarian Cancer21720365

Differential expressed protein
ACTHR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ACTHR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
COLI_HUMANACTHR_HUMANligand -> receptorHPMR
ACTHR_HUMANGNAS1_HUMANGPCR -> GproteingpDB
ACTHR_HUMANGNAS2_HUMANGPCR -> GproteingpDB
IP3KA_HUMANACTHR_HUMANotherKEGG
STF1_HUMANACTHR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0004978corticotropin receptor activityIEAmolecular_function
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004977melanocortin receptor activityTASmolecular_function
GO:0030819positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0005886plasma membraneTAScellular_component


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