| UniProt/SwissProt ID: | ACTHR_HUMAN |
| Description: | melanocortin 2 receptor (adrenocorticotropic hormone) [Source:HGNC Symbol;Acc:6930] |
| Location: | chr18 p11.21 |
| Node attribute: | PPI(target); GPCR; receptor; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T143 | YHSIVtMRRTV | 7tm_1 | PhosphoSitePlus |
| S280 | IYAFRsPELRD | PhosphoSitePlus | |
| S208 | HTRKIsTLPRA | 7tm_1 | PhosphoSitePlus |
| Dephosphorylation site |
| ACTHR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000382718 | R279W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000382718 | A135T | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000382718 | S180L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000382718 | E99K | COSMIC | Melanoma | 21499247 | ENSP00000382718 | L66M | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| ACTHR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ACTHR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| COLI_HUMAN | ACTHR_HUMAN | ligand -> receptor | HPMR |
| ACTHR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| ACTHR_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| IP3KA_HUMAN | ACTHR_HUMAN | other | KEGG |
| STF1_HUMAN | ACTHR_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004978 | corticotropin receptor activity | IEA | molecular_function |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004977 | melanocortin receptor activity | TAS | molecular_function |
| GO:0030819 | positive regulation of cAMP biosynthetic process | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |