| UniProt/SwissProt ID: | 5HT7R_HUMAN |
| Description: | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [Source:HGNC Symbol;Acc:5302] |
| Location: | chr10 q23.31 |
| Node attribute: | receptor; GPCR |
| Phosphorylation site |
| 5HT7R_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| 5HT7R_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000337949 | L378F | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| 5HT7R_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| 5HT7R_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TPH1_HUMAN | 5HT7R_HUMAN | ligand -> receptor | HPMR |
| 5HT7R_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| 5HT7R_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04726 | Serotonergic synapse |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007210 | serotonin receptor signaling pathway | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007623 | circadian rhythm | TAS | biological_process |
| GO:0004993 | serotonin receptor activity | IEA | molecular_function |
| GO:0008015 | blood circulation | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |