| UniProt/SwissProt ID: | SCTR_HUMAN |
| Description: | secretin receptor [Source:HGNC Symbol;Acc:10608] |
| Location: | chr2 q14.2 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S420 | PVASFsNSTKA | PhosphoSitePlus | |
| Y146 | KLKVMyTVGYS | 7tm_2; TM | PhosphoSitePlus |
| S418 | LHPVAsFSNST | PhosphoSitePlus | |
| S422 | ASFSNsTKASH | PhosphoSitePlus | |
| T423 | SFSNStKASHL | PhosphoSitePlus | |
| Dephosphorylation site |
| SCTR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000019103 | W112C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000019103 | D196N | COSMIC | Central Nervous System Neoplasms | 21163964 |
| Differential expressed protein |
| SCTR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SCTR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SECR_HUMAN | SCTR_HUMAN | ligand -> receptor | HPMR |
| SCTR_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| SCTR_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | SCTR_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04972 | Pancreatic secretion |
| hsa04976 | Bile secretion |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007586 | digestion | TAS | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0015055 | secretin receptor activity | TAS | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0004888 | transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007588 | excretion | TAS | biological_process |