| UniProt/SwissProt ID: | VIPR1_HUMAN |
| Description: | vasoactive intestinal peptide receptor 1 [Source:HGNC Symbol;Acc:12694] |
| Location: | chr3 p22.1 |
| Node attribute: | GPCR; receptor; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S165 | ATAILsLFRKL | TM; MspA; 7tm_2 | PhosphoSitePlus |
| S455 | FQAEVsLV___ | PhosphoSitePlus | |
| T429 | GSNGAtCSTQV | PhosphoSitePlus | |
| S447 | PGARRsSSFQA | PhosphoSitePlus | |
| S250 | AVSFFsERKYF | 7tm_2 | PhosphoSitePlus |
| S435 | CSTQVsMLTRV | PhosphoSitePlus | |
| Dephosphorylation site |
| VIPR1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000327246 | G257R | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| VIPR1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| VIPR1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| VIP_HUMAN | VIPR1_HUMAN | ligand -> receptor | HPMR |
| PACA_HUMAN | VIPR1_HUMAN | ligand -> receptor | HPMR |
| VIPR1_HUMAN | GNAS1_HUMAN | GPCR -> Gprotein | gpDB |
| VIPR1_HUMAN | GNAS2_HUMAN | GPCR -> Gprotein | gpDB |
| GLHA_HUMAN | VIPR1_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006955 | immune response | TAS | biological_process |
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0007586 | digestion | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006936 | muscle contraction | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0007187 | G-protein coupled receptor signaling pathway, coup | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004999 | vasoactive intestinal polypeptide receptor activit | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0004888 | transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |