| UniProt/SwissProt ID: | PTN5_HUMAN |
| Description: | protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) [Source:HGNC Symbol;Acc:9657] |
| Location: | chr11 p15.1 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S66 | PPSPPsDPAQK | PhosphoSitePlus | |
| T255 | TLDMCtPGCNE | PhosphoSitePlus | |
| S444 | LISLKsGTEER | Y_phosphatase | PhosphoSitePlus |
| S245 | QERRGsNVSLT | PhosphoSitePlus | |
| S268 | FGYLMsPREES | PhosphoSitePlus | |
| Dephosphorylation site |
| PTN5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379474 | G5R | COSMIC | Melanoma | 19074898 | ENSP00000351342 | T432M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351342 | G5R | COSMIC | Melanoma | 19074898 | ENSP00000379474 | E306K | COSMIC | Melanoma | 19074898 | ENSP00000379474 | T432M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351342 | E306K | COSMIC | Melanoma | 19074898 | ENSP00000379474 | K329E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351342 | P170A | COSMIC | Melanoma | 19074898 | ENSP00000351342 | K329E | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PTN5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTN5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTN5_HUMAN | FYN_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001784 | phosphotyrosine binding | IDA | molecular_function |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005789 | endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0016021 | integral to membrane | TAS | cellular_component |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |