Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ITCH_HUMAN
Description:itchy E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:13890]
Location:chr20 q11.22
Node attribute:substrate; ubiquitination(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S10GSQLGsMGSLTHPRD
Y589EEGLDyGGVARPhosphoSitePlus
S2SGSQHPRD
S450EKRTDsNGRVYWWPhosphoSitePlus
Y397ESVRNyEQWQLPhosphoSitePlus
Y343QHGRVyYVDHVWWPhosphoSitePlus
T15SMGSLtMKSQLHPRD
Y344HGRVYyVDHVEWWPhosphoSitePlus
Y420NQRFIyGNQDLFynphosphoELM; RegPhos
Y495VDGIPyFVDHNWWPhosphoSitePlus
Y420NQRFIyGNQDLPhosphoSitePlus
S13LGSMGsLTMKSHPRD
S393RPTLEsVRNYEPhosphoSitePlus
T385FTRTTtWQRPTWWPhosphoSitePlus
S4SQLGHPRD
Y524GPQIAyVRDFKPhosphoSitePlus

Dephosphorylation site
ITCH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363998E738QBIOMARTBreast Cancer21930507, 21930502
ENSP00000363998L724VCOSMICBreast Cancer20668451
ENSP00000363998E746QCOSMICBreast Cancer20668451
ENSP00000363998E718KBIOMARTBreast Cancer21930507, 21930502
ENSP00000363998I589VCOSMICLung Cancer20668451
ENSP00000363998E855KCOSMICBreast Cancer20668451
ENSP00000262650E779QBIOMARTBreast Cancer21930507, 21930502
ENSP00000262650E759KBIOMARTBreast Cancer21930507, 21930502
ENSP00000363998N750SCOSMICHead and Neck Cancer21798893
ENSP00000363998E238KBIOMARTBreast Cancer21930507, 21930502
ENSP00000262650E279KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ITCH_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ITCH_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FYN_HUMANITCH_HUMANkinase -> substrateRobert H Newman (2013)
ITCH_HUMANCFLAR_HUMANubiquitinationNetPath
ITCH_HUMANTGIF1_HUMANubiquitinationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa04120Ubiquitin mediated proteolysis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0042787protein ubiquitination involved in ubiquitin-depenIBAbiological_process
GO:0050687negative regulation of defense response to virusIEAbiological_process
GO:0043021ribonucleoprotein complex bindingIPImolecular_function
GO:0016567protein ubiquitinationIDAbiological_process
GO:0035519protein K29-linked ubiquitinationIDAbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0046642negative regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0032088negative regulation of NF-kappaB transcription facIEAbiological_process
GO:0050687negative regulation of defense response to virusIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0042787protein ubiquitination involved in ubiquitin-depenIEAbiological_process
GO:0046329negative regulation of JNK cascadeISSbiological_process
GO:0005634nucleusIBAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0045236CXCR chemokine receptor bindingIPImolecular_function
GO:0006511ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0045732positive regulation of protein catabolic processIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0006464cellular protein modification processIEAbiological_process
GO:0000209protein polyubiquitinationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0004842ubiquitin-protein ligase activityNASmolecular_function
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0032088negative regulation of NF-kappaB transcription facISSbiological_process
GO:0016874ligase activityIEAmolecular_function
GO:0001558regulation of cell growthNASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0090085regulation of protein deubiquitinationIEAbiological_process
GO:0006954inflammatory responseNASbiological_process
GO:0002669positive regulation of T cell anergyIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005938cell cortexIEAcellular_component
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0046718viral entry into host cellTASbiological_process
GO:0032480negative regulation of type I interferon productioTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0090085regulation of protein deubiquitinationISSbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0070936protein K48-linked ubiquitinationIDAbiological_process
GO:0046329negative regulation of JNK cascadeIEAbiological_process