Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CNN3_HUMAN
Description:calponin 3, acidic [Source:HGNC Symbol;Acc:2157]
Location:chr1 p21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S244DNSTIsLQMGTCalponinPhosphoSitePlus; SysPTM
S285VIHNGsQGTGTPhosphoSitePlus
Y308EYPDEyHGEYQPhosphoSitePlus
Y316EYQDDyPRDYQPhosphoSitePlus
S43EVTGMsIGPNFCHPhosphoSitePlus
S323RDYQYsDQGIDPhosphoSitePlus; RegPhos; SysPTM
T234YDQKLtLQPVDPhosphoSitePlus
S162LKAGQsVIGLQPhosphoSitePlus; HPRD; SysPTM
Y322PRDYQySDQGIPhosphoSitePlus
T184MTAYGtRRHLYCalponinPhosphoSitePlus
Y300ISDSDyQAEYPPhosphoSitePlus
T242PVDNStISLQMPhosphoSitePlus
S323RDYQYsDQGIHPRD; phosphoELM; SysPTM
S254TNKVAsQKGMSCalponinPhosphoSitePlus
Y10NKGPSyGLSAEPhosphoSitePlus
Y261KGMSVyGLGRQFYNHPRD; RegPhos
S293TGTNGsEISDSPhosphoSitePlus
T2____MtHFNKGPhosphoSitePlus
S244DNSTIsLQMGTHPRD; phosphoELM; RegPhos; SysPTM
Y261KGMSVyGLGRQCalponinPhosphoSitePlus
Y182AGMTAyGTRRHCalponinPhosphoSitePlus
Y261KGMSVyGLGRQphosphoELM
T290SQGTGtNGSEIHPRD
S296NGSEIsDSDYQPhosphoSitePlus; HPRD

Dephosphorylation site
CNN3_HUMAN do not have dephosphorylation site.

Mutation site
CNN3_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000359225Hepatocellular CarcinomaNormal vs. Cancercell lineUp1118646787
ENSP00000359225Hepatocellular CarcinomaNormal vs. Cancercell lineUp1418646787
ENSP00000359225Esophageal CancerNormal vs. CancertissueDown0.3619142970

Hyperphosphorylation site
CNN3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FYN_HUMANCNN3_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANCNN3_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
CNN3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005516calmodulin bindingNASmolecular_function
GO:0005575cellular_componentNDcellular_component
GO:0006939smooth muscle contractionNASbiological_process
GO:0014069postsynaptic densityIEAcellular_component
GO:0030172troponin C bindingNASmolecular_function
GO:0032780negative regulation of ATPase activityIEAbiological_process
GO:0031032actomyosin structure organizationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0008017microtubule bindingIEAmolecular_function
GO:0043025neuronal cell bodyIEAcellular_component
GO:0003779actin bindingIEAmolecular_function
GO:0005523tropomyosin bindingNASmolecular_function


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