| UniProt/SwissProt ID: | RHG33_HUMAN |
| Description: | Rho GTPase activating protein 33 [Source:HGNC Symbol;Acc:23085] |
| Location: | chr19 q13.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T628 | GSRPDtVTLRS | PhosphoSitePlus | |
| Y442 | YRTLEyLLRHL | RhoGAP | PhosphoSitePlus |
| S624 | PQPSGsRPDTV | PhosphoSitePlus | |
| S636 | LRSAKsEESLS | PhosphoSitePlus | |
| T630 | RPDTVtLRSAK | PhosphoSitePlus | |
| T558 | QGRLGtPTEPT | PhosphoSitePlus; HPRD | |
| T552 | EAQARtQGRLG | PhosphoSitePlus; HPRD | |
| S182 | LSEEAsLNIPA | PhosphoSitePlus | |
| T564 | PTEPTtPKAPA | PhosphoSitePlus | |
| S178 | RRLLLsEEASL | PhosphoSitePlus | |
| T560 | RLGTPtEPTTP | PhosphoSitePlus; HPRD | |
| Y406 | LTYQLyGKFSE | RhoGAP | PhosphoSitePlus |
| Y406 | LTYQLyGKFSE | FYN | HPRD |
| Dephosphorylation site |
| RHG33_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000320038 | P371S | COSMIC | Melanoma | ENSP00000320038 | A856V | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000320038 | G668S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000320038 | E441* | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| RHG33_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RHG33_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FYN_HUMAN | RHG33_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | RHG33_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| RHG33_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0032321 | positive regulation of Rho GTPase activity | IEA | biological_process |
| GO:0032855 | positive regulation of Rac GTPase activity | IEA | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0030675 | Rac GTPase activator activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005100 | Rho GTPase activator activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |