| UniProt/SwissProt ID: | BFAR_HUMAN |
| Description: | bifunctional apoptosis regulator [Source:HGNC Symbol;Acc:17613] |
| Location: | chr16 p13.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y8 | EPQKSyVNTMD | PhosphoSitePlus | |
| S376 | VLELFsFWRIW | TM | PhosphoSitePlus |
| Dephosphorylation site |
| BFAR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261658 | S165N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000261658 | S165N | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| BFAR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| BFAR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | BFAR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK14_HUMAN | BFAR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | BFAR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK11_HUMAN | BFAR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAF1_HUMAN | BFAR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FYN_HUMAN | BFAR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BFAR_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0005789 | endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IDA | biological_process |
| GO:0005198 | structural molecule activity | TAS | molecular_function |