| UniProt/SwissProt ID: | FYB_HUMAN |
| Description: | FYN binding protein [Source:HGNC Symbol;Acc:4036] |
| Location: | chr5 p13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y462 | SEGETyEDIEA | Ycf1 | PhosphoSitePlus |
| Y571 | AVEIDyDSLKL | Ycf1 | PhosphoSitePlus; SysPTM |
| S432 | PFDLKsPVNED | Ycf1 | PhosphoSitePlus |
| S46 | NQGNAsPPAGP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y595 | DDQEVyDDVAE | Ycf1 | PhosphoSitePlus |
| Y801 | NEEGKyGYVLR | HPRD | |
| Y697 | MGDEVyDDVDT | FYN | HPRD |
| S386 | SKGQTsYSTTS | PhosphoSitePlus | |
| T161 | GPTPPtSENEQ | PhosphoSitePlus; HPRD | |
| Y757 | EGKYGyVLRSY | PhosphoSitePlus; HPRD; RegPhos | |
| S245 | PAREDsENKDH | PhosphoSitePlus | |
| S28 | VTGPNsSSGIQ | RegPhos | |
| Y780 | ADGCIyDND__ | PhosphoSitePlus | |
| S457 | DEEQDsEGETY | Ycf1 | PhosphoSitePlus |
| T461 | DSEGEtYEDIE | Ycf1 | PhosphoSitePlus |
| T385 | TSKGQtSYSTT | PhosphoSitePlus | |
| S222 | KNVSSsKGSPA | PhosphoSitePlus | |
| S573 | EIDYDsLKLKK | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y595 | DDQEVyDDVAE | FYN | HPRD; RegPhos |
| S306 | QEELAsGTPPA | PhosphoSitePlus | |
| Y595 | DDQEVyDDVAE | Fyn | phosphoELM; RegPhos |
| Y387 | KGQTSySTTSL | PhosphoSitePlus | |
| Y803 | EGKYGyVLRSY | HPRD | |
| S573 | EIDYDsLKLKK | Ycf1 | PhosphoSitePlus; SysPTM |
| S225 | SSSKGsPAPLG | PhosphoSitePlus | |
| Y4 | __MAKyNTGGN | PhosphoSitePlus | |
| S233 | PLGVRsKSGPL | PhosphoSitePlus | |
| Y559 | TARGSyGYIKT | Ycf1; SH3_2 | PhosphoSitePlus |
| Y651 | MGDEVyDDVDT | Fyn | phosphoELM; RegPhos |
| Y625 | PDDDIyDGIEE | Ycf1 | PhosphoSitePlus |
| T374 | TKFHKtSSGNS | PhosphoSitePlus | |
| Y755 | NEEGKyGYVLR | PhosphoSitePlus; HPRD; RegPhos | |
| Y651 | MGDEVyDDVDT | FYN | HPRD; RegPhos |
| Y561 | RGSYGyIKTTA | Ycf1; SH3_2 | PhosphoSitePlus |
| S209 | LSTENsHEDES | PhosphoSitePlus | |
| T711 | RVLYStKVTTS | HPRD | |
| Y771 | NDGEIyDDIAD | PhosphoSitePlus | |
| T656 | YDDVDtSDFPV | Ycf1 | PhosphoSitePlus |
| T308 | ELASGtPPARF | PhosphoSitePlus | |
| T158 | PKSGPtPPTSE | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y762 | YVLRSyLADND | PhosphoSitePlus | |
| Y701 | RKKFKyDGEIR | Ycf1 | PhosphoSitePlus |
| Y651 | MGDEVyDDVDT | Ycf1 | PhosphoSitePlus |
| T757 | RVLYStKVTTS | HPRD | |
| Y571 | AVEIDyDSLKL | HPRD; phosphoELM; RegPhos; SysPTM | |
| S558 | RTARGsYGYIK | Ycf1; SH3_2 | PhosphoSitePlus |
| T507 | KKFKLtGPIQV | Ycf1 | PhosphoSitePlus |
| Dephosphorylation site |
| FYB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316460 | G548* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316460 | R556M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000316460 | P584L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| FYB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FYB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | FYB_HUMAN | kinase -> substrate | RegPhos |
| FYN_HUMAN | FYB_HUMAN | kinase -> substrate | RegPhos; NetPath; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FYB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008150 | biological_process | ND | biological_process |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0006607 | NLS-bearing substrate import into nucleus | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0032403 | protein complex binding | IEA | molecular_function |
| GO:0007243 | intracellular protein kinase cascade | TAS | biological_process |