| UniProt/SwissProt ID: | NMT1_HUMAN |
| Description: | N-myristoyltransferase 1 [Source:HGNC Symbol;Acc:7857] |
| Location: | chr17 q21.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S83 | PVKMNsLPAER | NST1 | PhosphoSitePlus |
| T52 | SPANDtGAKKK | NST1 | PhosphoSitePlus |
| Y180 | LLNENyVEDDD | Fyn | phosphoELM; RegPhos |
| Y180 | LLNENyVEDDD | FYN | HPRD; RegPhos |
| T427 | FYNVHtQTPLL | NMT_C; Acetyltransf_3 | PhosphoSitePlus |
| T71 | EKGSEtDSAQD | NST1 | PhosphoSitePlus |
| Y180 | LLNENyVEDDD | LYN | HPRD; RegPhos |
| S31 | GHEHCsDCENE | RegPhos | |
| Y180 | LLNENyVEDDD | Lyn | phosphoELM; RegPhos |
| T343 | LRPMEtKDIPV | NMT_C; Acetyltransf_3 | PhosphoSitePlus |
| T319 | LSRNMtMQRTM | NMT_C | PhosphoSitePlus |
| Y180 | LLNENyVEDDD | NMT | PhosphoSitePlus |
| Y117 | ASKRSyQFWDT | Lyn | phosphoELM; RegPhos |
| S47 | NRGGLsPANDT | HPRD; phosphoELM; RegPhos; SysPTM | |
| S47 | NRGGLsPANDT | NST1 | PhosphoSitePlus; SysPTM |
| Dephosphorylation site |
| NMT1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000258960 | Y476C | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000258960 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| NMT1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| LYN_HUMAN | NMT1_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | NMT1_HUMAN | kinase -> substrate | RegPhos |
| FYN_HUMAN | NMT1_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NMT1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004379 | glycylpeptide N-tetradecanoyltransferase activity | IEA | molecular_function |
| GO:0006498 | N-terminal protein lipidation | NAS | biological_process |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0015629 | actin cytoskeleton | IDA | cellular_component |
| GO:0009249 | protein lipoylation | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0006499 | N-terminal protein myristoylation | IEA | biological_process |
| GO:0006915 | apoptotic process | TAS | biological_process |
| GO:0003824 | catalytic activity | TAS | molecular_function |
| GO:0030054 | cell junction | IDA | cellular_component |