| UniProt/SwissProt ID: | CNN1_HUMAN |
| Description: | calponin 1, basic, smooth muscle [Source:HGNC Symbol;Acc:2155] |
| Location: | chr19 p13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y294 | HAHNYyNSA__ | PhosphoSitePlus | |
| Y293 | HHAHNyYNSA_ | PhosphoSitePlus | |
| Y182 | QGMTAyGTRRH | Calponin | PhosphoSitePlus |
| Y261 | RGMTVyGLPRQ | Calponin | PhosphoSitePlus |
| T184 | MTAYGtRRHLY | Calponin | PhosphoSitePlus |
| T180 | SQQGMtAYGTR | Calponin | PhosphoSitePlus |
| Y189 | TRRHLyDPKLG | Calponin | PhosphoSitePlus |
| Y26 | KLAQKyDHQRE | PhosphoSitePlus | |
| S2 | ____MsSAHFN | PhosphoSitePlus | |
| Y261 | RGMTVyGLPRQ | FYN | HPRD |
| Y12 | NRGPAyGLSAE | PhosphoSitePlus | |
| Y278 | CLTPEyPELGE | PhosphoSitePlus | |
| S3 | ___MSsAHFNR | PhosphoSitePlus | |
| Y182 | QGMTAyGTRRH | FYN | HPRD |
| Dephosphorylation site |
| CNN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CNN1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000252456 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 5.8 | 17929853 | ENSP00000252456 | Gastric Cancer | Cancer vs. Cancer (good vs. proo survival) | tissue | Up | 3.3 | 18830628 | ENSP00000252456 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.29 | 16400690 | ENSP00000252456 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.35 | 16400690 |
| Hyperphosphorylation site |
| CNN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FYN_HUMAN | CNN1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| CNN1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005516 | calmodulin binding | IEA | molecular_function |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0031032 | actomyosin structure organization | IEA | biological_process |
| GO:0005856 | cytoskeleton | IDA | cellular_component |
| GO:0006940 | regulation of smooth muscle contraction | TAS | biological_process |