| UniProt/SwissProt ID: | NU133_HUMAN |
| Description: | nucleoporin 133kDa [Source:HGNC Symbol;Acc:18016] |
| Location: | chr1 q42.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S261 | GRKVSsLFGIL | Nucleoporin_N | PhosphoSitePlus |
| S56 | PVGRRsSLSSR | PhosphoSitePlus | |
| T13 | PRTPGtGSRRG | HPRD | |
| T1027 | AMPVLtAPQLI | Nucleoporin_C | PhosphoSitePlus |
| S267 | LFGILsPSSDL | HPRD; phosphoELM | |
| S1086 | DNWSSsDGKDD | Nucleoporin_C | PhosphoSitePlus |
| Y1150 | KANYEyYVQGQ | PhosphoSitePlus | |
| S72 | MFPHHsITESV | PhosphoSitePlus; HPRD; phosphoELM | |
| S547 | DELFSsHSDLD | HPRD | |
| T10 | APSPRtPGTGS | PhosphoSitePlus; HPRD; phosphoELM | |
| S223 | GSFILsSSGSQ | Nucleoporin_N | PhosphoSitePlus |
| S450 | NAQGDsVLGAG | HPRD | |
| S44 | LGSAVsSPVLF | PhosphoSitePlus; HPRD; phosphoELM | |
| S59 | RRSSLsSRGTP | PhosphoSitePlus; HPRD | |
| S1085 | RDNWSsSDGKD | Nucleoporin_C | PhosphoSitePlus |
| Y1046 | RRANEyDFKKA | Nucleoporin_C | PhosphoSitePlus |
| S57 | VGRRSsLSSRG | PhosphoSitePlus; HPRD | |
| T31 | GSTPRtASRKG | PhosphoSitePlus; HPRD; phosphoELM | |
| T74 | PHHSItESVNY | Nucleoporin_N | PhosphoSitePlus |
| S7 | FPAAPsPRTPG | PhosphoSitePlus; SysPTM | |
| S553 | HSDLDsDSELD | PhosphoSitePlus; phosphoELM | |
| S15 | TPGTGsRRGPL | PhosphoSitePlus; HPRD | |
| S1084 | QRDNWsSSDGK | Nucleoporin_C | PhosphoSitePlus |
| S45 | GSAVSsPVLFS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S131 | WKIALsPITKL | HPRD; phosphoELM | |
| T63 | LSSRGtPTRMF | PhosphoSitePlus; HPRD; phosphoELM | |
| T28 | LGPGStPRTAS | PhosphoSitePlus; HPRD; phosphoELM | |
| S33 | TPRTAsRKGLP | PhosphoSitePlus; HPRD; phosphoELM | |
| S131 | WKIALsPITKL | Nucleoporin_N | PhosphoSitePlus |
| S489 | EDLEGsLASSV | HPRD | |
| T512 | TTKNEtIAQED | PhosphoSitePlus; HPRD; phosphoELM | |
| S27 | GLGPGsTPRTA | PhosphoSitePlus; HPRD; phosphoELM | |
| S549 | LFSSHsDLDSD | HPRD | |
| S50 | SPVLFsPVGRR | PhosphoSitePlus; HPRD; phosphoELM | |
| S41 | GLPLGsAVSSP | PhosphoSitePlus; HPRD; phosphoELM | |
| T213 | TYSFLtAVQGG | Nucleoporin_N | PhosphoSitePlus |
| S546 | VDELFsSHSDL | HPRD | |
| S7 | RTPG | HPRD; SysPTM | |
| S260 | IGRKVsSLFGI | Nucleoporin_N | PhosphoSitePlus |
| S267 | LFGILsPSSDL | Nucleoporin_N | PhosphoSitePlus |
| S480 | SRENVsILAED | PhosphoSitePlus | |
| S499 | VAGPNsESMIF | PhosphoSitePlus; phosphoELM | |
| T969 | FAKKKtLLGLS | Nucleoporin_C | PhosphoSitePlus |
| T65 | SRGTPtRMFPH | HPRD | |
| T134 | ALSPItKLSVC | HPRD | |
| S60 | RSSLSsRGTPT | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| NU133_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261396 | R341Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000261396 | M735I | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000261396 | T969P | COSMIC | Melanoma | 21499247 | ENSP00000261396 | S361L | COSMIC | Breast Cancer | ENSP00000261396 | G448R | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000261396 | E864K | COSMIC | Skin Cancer | 21984974 | ENSP00000261396 | G326V | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000261396 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| NU133_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK7_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK9_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| JAK2_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | NU133_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NU133_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
| GO:0031080 | nuclear pore outer ring | IDA | cellular_component |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0005643 | nuclear pore | IDA | cellular_component |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0000940 | condensed chromosome outer kinetochore | IDA | cellular_component |
| GO:0006406 | mRNA export from nucleus | IDA | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0005487 | nucleocytoplasmic transporter activity | IDA | molecular_function |
| GO:0000777 | condensed chromosome kinetochore | IDA | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0006999 | nuclear pore organization | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0015758 | glucose transport | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0010827 | regulation of glucose transport | TAS | biological_process |
| GO:0008645 | hexose transport | TAS | biological_process |
| GO:0005635 | nuclear envelope | TAS | cellular_component |
| GO:0048339 | paraxial mesoderm development | IEA | biological_process |