Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NU133_HUMAN
Description:nucleoporin 133kDa [Source:HGNC Symbol;Acc:18016]
Location:chr1 q42.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S261GRKVSsLFGILNucleoporin_NPhosphoSitePlus
S56PVGRRsSLSSRPhosphoSitePlus
T13PRTPGtGSRRGHPRD
T1027AMPVLtAPQLINucleoporin_CPhosphoSitePlus
S267LFGILsPSSDLHPRD; phosphoELM
S1086DNWSSsDGKDDNucleoporin_CPhosphoSitePlus
Y1150KANYEyYVQGQPhosphoSitePlus
S72MFPHHsITESVPhosphoSitePlus; HPRD; phosphoELM
S547DELFSsHSDLDHPRD
T10APSPRtPGTGSPhosphoSitePlus; HPRD; phosphoELM
S223GSFILsSSGSQNucleoporin_NPhosphoSitePlus
S450NAQGDsVLGAGHPRD
S44LGSAVsSPVLFPhosphoSitePlus; HPRD; phosphoELM
S59RRSSLsSRGTPPhosphoSitePlus; HPRD
S1085RDNWSsSDGKDNucleoporin_CPhosphoSitePlus
Y1046RRANEyDFKKANucleoporin_CPhosphoSitePlus
S57VGRRSsLSSRGPhosphoSitePlus; HPRD
T31GSTPRtASRKGPhosphoSitePlus; HPRD; phosphoELM
T74PHHSItESVNYNucleoporin_NPhosphoSitePlus
S7FPAAPsPRTPGPhosphoSitePlus; SysPTM
S553HSDLDsDSELDPhosphoSitePlus; phosphoELM
S15TPGTGsRRGPLPhosphoSitePlus; HPRD
S1084QRDNWsSSDGKNucleoporin_CPhosphoSitePlus
S45GSAVSsPVLFSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S131WKIALsPITKLHPRD; phosphoELM
T63LSSRGtPTRMFPhosphoSitePlus; HPRD; phosphoELM
T28LGPGStPRTASPhosphoSitePlus; HPRD; phosphoELM
S33TPRTAsRKGLPPhosphoSitePlus; HPRD; phosphoELM
S131WKIALsPITKLNucleoporin_NPhosphoSitePlus
S489EDLEGsLASSVHPRD
T512TTKNEtIAQEDPhosphoSitePlus; HPRD; phosphoELM
S27GLGPGsTPRTAPhosphoSitePlus; HPRD; phosphoELM
S549LFSSHsDLDSDHPRD
S50SPVLFsPVGRRPhosphoSitePlus; HPRD; phosphoELM
S41GLPLGsAVSSPPhosphoSitePlus; HPRD; phosphoELM
T213TYSFLtAVQGGNucleoporin_NPhosphoSitePlus
S546VDELFsSHSDLHPRD
S7RTPGHPRD; SysPTM
S260IGRKVsSLFGINucleoporin_NPhosphoSitePlus
S267LFGILsPSSDLNucleoporin_NPhosphoSitePlus
S480SRENVsILAEDPhosphoSitePlus
S499VAGPNsESMIFPhosphoSitePlus; phosphoELM
T969FAKKKtLLGLSNucleoporin_CPhosphoSitePlus
T65SRGTPtRMFPHHPRD
T134ALSPItKLSVCHPRD
S60RSSLSsRGTPTPhosphoSitePlus; HPRD

Dephosphorylation site
NU133_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261396R341QCOSMICOvarian Cancer21720365
ENSP00000261396M735IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000261396T969PCOSMICMelanoma21499247
ENSP00000261396S361LCOSMICBreast Cancer
ENSP00000261396G448RSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000261396E864KCOSMICSkin Cancer21984974
ENSP00000261396G326VSjoblom2006, COSMIC, HPIBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261396Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
NU133_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK7_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANNU133_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NU133_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0031080nuclear pore outer ringIDAcellular_component
GO:0016032viral reproductionTASbiological_process
GO:0005643nuclear poreIDAcellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0000940condensed chromosome outer kinetochoreIDAcellular_component
GO:0006406mRNA export from nucleusIDAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0005487nucleocytoplasmic transporter activityIDAmolecular_function
GO:0000777condensed chromosome kinetochoreIDAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000236mitotic prometaphaseTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0006999nuclear pore organizationIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0015758glucose transportTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0010827regulation of glucose transportTASbiological_process
GO:0008645hexose transportTASbiological_process
GO:0005635nuclear envelopeTAScellular_component
GO:0048339paraxial mesoderm developmentIEAbiological_process


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