| UniProt/SwissProt ID: | RBL1_HUMAN |
| Description: | retinoblastoma-like 1 (p107) [Source:HGNC Symbol;Acc:9893] |
| Location: | chr20 q11.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T369 | SFAPStPLTGR | CDK4 | HPRD; phosphoELM; RegPhos |
| S640 | DMQPLsPISVH | PhosphoSitePlus; HPRD; RegPhos | |
| T652 | RYSSPtAGSAK | PhosphoSitePlus | |
| T88 | NCVSLtRILRS | DUF3452 | PhosphoSitePlus |
| T369 | SFAPStPLTGR | PhosphoSitePlus | |
| T385 | KEAVItPVASA | HPRD; phosphoELM; RegPhos | |
| Y949 | SFALKyDLANQ | PhosphoSitePlus | |
| S650 | HERYSsPTAGS | CDK4 | HPRD; phosphoELM; RegPhos |
| S1000 | GLTPRsALLYK | Rb_C | PhosphoSitePlus |
| S643 | PLSPIsVHERY | PhosphoSitePlus | |
| S975 | KQQPGsPRRIS | HPRD; RegPhos | |
| S988 | HSIYIsPHKNG | Rb_C | PhosphoSitePlus |
| S650 | HERYSsPTAGS | PhosphoSitePlus; RegPhos | |
| S762 | SLIGAsPKQTN | CDK2 | RegPhos |
| T997 | NGSGLtPRSAL | CDK2 | RegPhos |
| T385 | KEAVItPVASA | RB_A | PhosphoSitePlus |
| S762 | SLIGAsPKQTN | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S103 | LIQFFsKMKKW | HPRD | |
| Y469 | AEILYyKILET | RB_A | PhosphoSitePlus |
| S93 | TRILRsAKLSL | HPRD | |
| S1009 | YKFNGsPSK | HPRD | |
| S919 | KTPDCsSGPVK | RB_B | PhosphoSitePlus |
| Y938 | FYNTIyVGRVK | RB_B | PhosphoSitePlus |
| S1009 | YKFNGsPSKSL | CDK2 | RegPhos |
| S994 | PHKNGsGLTPR | HPRD | |
| T385 | KEAVItPVASA | CDK2 | RegPhos |
| S1041 | DSDAEsPAKRV | Rb_C | PhosphoSitePlus |
| Y1004 | RSALLyKFNGS | Rb_C | PhosphoSitePlus |
| S964 | DAPPLsPFPHI | CDK4 | HPRD; phosphoELM; RegPhos |
| S1011 | FNGSPsKSLKD | Rb_C | PhosphoSitePlus |
| S615 | PLMPMsPLMHP | HPRD; phosphoELM; RegPhos | |
| T997 | NGSGLtPRSAL | Rb_C | PhosphoSitePlus |
| T340 | KFTRDtPLGKL | HPRD; phosphoELM; RegPhos | |
| S749 | ESKVKsPVSLT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S757 | SLTAHsLIGAS | PhosphoSitePlus | |
| S1037 | VIAIDsDAESP | Rb_C | PhosphoSitePlus |
| S975 | KQQPGsPRRIS | Rb_C | PhosphoSitePlus |
| T332 | EEEIGtPRKFT | CDK2 | RegPhos |
| T372 | PSTPLtGRRYL | PhosphoSitePlus | |
| S984 | ISQQHsIYISP | Rb_C | PhosphoSitePlus |
| T769 | KQTNLtKAQEV | PhosphoSitePlus | |
| S1041 | DSDAEsPAKRV | HPRD; phosphoELM; RegPhos | |
| S964 | DAPPLsPFPHI | CDK2 | RegPhos |
| S1009 | YKFNGsPSKSL | HPRD; phosphoELM; RegPhos | |
| S975 | KQQPGsPRRIS | CDK2 | RegPhos |
| S93 | TRILRsAKLSL | DUF3452 | PhosphoSitePlus |
| S984 | ISQQHsIYISP | HPRD | |
| T332 | EEEIGtPRKFT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S368 | RSFAPsTPLTG | PhosphoSitePlus | |
| S988 | HSIYIsPHKNG | HPRD; phosphoELM; RegPhos | |
| T915 | EDATKtPDCSS | RB_B | PhosphoSitePlus |
| Y468 | LAEILyYKILE | RB_A | PhosphoSitePlus |
| S988 | HSIYIsPHKNG | CDK2 | RegPhos |
| S994 | PHKNGsGLTPR | Rb_C | PhosphoSitePlus |
| S975 | KQQPGsPRRIS | CDK4 | phosphoELM; RegPhos |
| Y986 | QQHSIyISPHK | HPRD | |
| Y792 | SLALFyRKVYH | RB_B | PhosphoSitePlus |
| S640 | DMQPLsPISVH | CDK2 | RegPhos |
| S640 | DMQPLsPISVH | CDK4 | phosphoELM; RegPhos |
| T997 | NGSGLtPRSAL | HPRD; phosphoELM; RegPhos | |
| S964 | DAPPLsPFPHI | Rb_C | PhosphoSitePlus |
| S103 | LIQFFsKMKKW | DUF3452 | PhosphoSitePlus |
| Dephosphorylation site |
| RBL1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362768 | N422S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000343646 | N422S | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000362768 | R92L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000362768 | L491F | COSMIC | Skin Cancer | 21984974 | ENSP00000362768 | V622F | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000362768 | K137Q | COSMIC | Melanoma | 21499247 | ENSP00000343646 | S695L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000362768 | V251A | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000362768 | S500F | COSMIC | Melanoma | 21499247 | ENSP00000362768 | G323R | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000362768 | K794N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000362768 | W568C | COSMIC | Lung Cancer | ENSP00000362768 | S695L | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| RBL1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RBL1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | RBL1_HUMAN | kinase -> substrate | RegPhos |
| CDK4_HUMAN | RBL1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | RBL1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04350 | TGF-beta signaling pathway |
| hsa05203 | Viral carcinogenesis |
| hsa04110 | Cell cycle |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | TAS | biological_process |
| GO:0000080 | G1 phase of mitotic cell cycle | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006367 | transcription initiation from RNA polymerase II pr | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0043550 | regulation of lipid kinase activity | IDA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0016568 | chromatin modification | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0007179 | transforming growth factor beta receptor signaling | TAS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | TAS | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |