Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:G3P_HUMAN
Description:glyceraldehyde-3-phosphate dehydrogenase [Source:HGNC Symbol;Acc:4141]
Location:chr12 p13.31
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T176VEGLMtTVHAIGp_dh_CPhosphoSitePlus
S210NIIPAsTGAAKHPRD
T99YVVEStGVFTTGp_dh_NPhosphoSitePlus
Y42FIDLNyMVYMFGp_dh_NPhosphoSitePlus
T211IIPAStGAAKAGp_dh_CPhosphoSitePlus
T103STGVFtTMEKAGp_dh_NPhosphoSitePlus
S312FVKLIsWYDNEGp_dh_CPhosphoSitePlus
Y255EKPAKyDDIKKGp_dh_CPhosphoSitePlus
Y276KGILGyTEHQVGp_dh_CPhosphoSitePlus
T211IIPAStGAAKAHPRD
T176VEGLMtTVHAIHPRD
T59GKFHGtVKAENHPRD
S151IISNAsCTTNCHPRD; SysPTM
T104TGVFTtMEKAGGp_dh_NPhosphoSitePlus
T75NGNPItIFQERGp_dh_NPhosphoSitePlus
S25RAAFNsGKVDIGp_dh_NPhosphoSitePlus
Y49VYMFQyDSTHGGp_dh_NPhosphoSitePlus
T246SVVDLtCRLEKGp_dh_CPhosphoSitePlus
Y45LNYMVyMFQYDGp_dh_NPhosphoSitePlus
S143EKYDNsLKIISGp_dh_NPhosphoSitePlus
T246SVVDLtCRLEKHPRD
S266VVKQAsEGPLKGp_dh_CPhosphoSitePlus
Y140VNHEKyDNSLKGp_dh_NPhosphoSitePlus
T52FQYDStHGKFHGp_dh_NPhosphoSitePlus
T187TATQKtVDGPSGp_dh_CPhosphoSitePlus
T182TVHAItATQKTGp_dh_CPhosphoSitePlus
T237AFRVPtANVSVGp_dh_CPhosphoSitePlus
T177EGLMTtVHAITGp_dh_CPhosphoSitePlus
S210NIIPAsTGAAKGp_dh_CPhosphoSitePlus
T75NGNPItIFQERHPRD
T153SNASCtTNCLAPhosphoSitePlus
S51MFQYDsTHGKFGp_dh_NPhosphoSitePlus
S284HQVVSsDFNSDGp_dh_CPhosphoSitePlus
S25RAAFNsGKVDIHPRD
T59GKFHGtVKAENGp_dh_NPhosphoSitePlus
S83QERDPsKIKWGHPRD; phosphoELM; SysPTM
T154NASCTtNCLAPPhosphoSitePlus; HPRD
Y320DNEFGySNRVVPhosphoSitePlus
S333MAHMAsKE___PhosphoSitePlus
T184HAITAtQKTVDHPRD; SysPTM
T184HAITAtQKTVDGp_dh_CPhosphoSitePlus; SysPTM
S83QERDPsKIKWGGp_dh_NPhosphoSitePlus; SysPTM
S192TVDGPsGKLWRGp_dh_CPhosphoSitePlus
Y314KLISWyDNEFGGp_dh_CPhosphoSitePlus
Y94DAGAEyVVESTGp_dh_NPhosphoSitePlus
Y42FIDLNyMVYMFHPRD
S151IISNAsCTTNCGp_dh_NPhosphoSitePlus; SysPTM
S148SLKIIsNASCTGp_dh_NPhosphoSitePlus
T182TVHAItATQKTHPRD

Dephosphorylation site
G3P_HUMAN do not have dephosphorylation site.

Mutation site
G3P_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000380068Pancreatic CancerNormal vs. CancertissueDown0.2416215274
ENSP00000380068Breast CancerTreatment (none vs. SEL1L treatment)cell lineUp3.415880780
ENSP00000380068Hepatocellular CarcinomaNormal vs. CancertissueDown0.4917627933
ENSP00000380068Hepatocellular CarcinomaNormal vs. CancertissueUp2.417627933
ENSP00000380068papillary thyroid carcinomaNormal vs. CancertissueUp3.918665625
ENSP00000380068papillary thyroid carcinomaNormal vs. CancertissueUp3.118665625
ENSP00000380068Oral Premalignant LesionsNormal vs. CancertissueUp1.419072117
ENSP00000380068Oral Premalignant LesionsNormal vs. CancertissueUp1.619072117
ENSP00000380068Oral Premalignant LesionsNormal vs. CancertissueDown0.7519072117
ENSP00000380068Oral Premalignant LesionsNormal vs. CancertissueUp1.519072117
ENSP00000380068Oral Premalignant LesionsNormal vs. CancertissueUp1.119072117
ENSP00000380068Oral Premalignant LesionsNormal vs. CancertissueUp1.119072117
ENSP00000380068breast ductal carcinomaNormal vs. CancertissueUp18482919
ENSP00000380068Breast CancerNormal vs. CancertissueDown0.215767701
ENSP00000380068MelanomaTreatment (none vs. metastasis suppressor 1 (BRMS1) overEXPressed)cell lineDown0.5317854218
ENSP00000380068Hepatocellular CarcinomaNormal vs. CancertissueUp1.911866469
ENSP00000380068Hepatocellular CarcinomaNormal vs. Cancercell lineDown17214954
ENSP00000380068Hepatocellular CarcinomaMetastasiscell lineUp17214954
ENSP00000380068Hepatocellular CarcinomaCancer vs. Cancer (HCC vs. HuCCA)cell lineUp20069059
ENSP00000380068Colorectal CancerTreatment (none vs transfected with HPV-16 E6 gene)cell lineUp15684709
ENSP00000380068Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000380068Neoplasms by Histologic TypeCancer vs. Cancercell lineUp15750928
ENSP00000380068Lung CancerCancer vs. Cancercell lineUp17284061
ENSP00000380068Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.120804217
ENSP00000380068Gastric CancerTreatment (none vs. 5-fluorouracil treatment)cell lineUp2316900703
ENSP00000380068Gastric CancerNormal vs. CancertissueUp5.318723843
ENSP00000380068Breast CancerNormal vs. Cancercell lineDown0.5820052998
ENSP00000380068Breast CancerNormal vs. Cancercell lineDown0.8920052998
ENSP00000380068Breast CancerMetastasiscell lineUp1.620052998
ENSP00000380068Breast CancerNormal vs. CancertissueUp2.920087651
ENSP00000380068breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000380068Renal CancerNormal vs. CancertissueUp2.0-3.312923786
ENSP00000380068Renal CancerNormal vs. CancertissueUp2.1-5.412923786
ENSP00000380068Renal CancerNormal vs. CancertissueUp2.319610612
ENSP00000380068Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000380068Ovarian CancerMetastasiscell lineDown17892554
ENSP00000380068Esophageal CancerNormal vs. Cancercell lineDown0.2719090015
ENSP00000380068Esophageal CancerNormal vs. Cancercell lineDown0.2919090015
ENSP00000380068Gastric CancerNormal vs. CancertissueDown0.3415761955
ENSP00000380068Gastric CancerNormal vs. CancertissueDown0.4815761955
ENSP00000380068Uterine CancerCancer vs. Cancercell lineUp17616526
ENSP00000380068Uterine CancerCancer vs. Cancercell lineUp17616526
ENSP00000380068Uterine CancerTreatment(21% oxygen vs. 1% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000380068Uterine CancerTreatment(21% oxygen vs. 0% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000380068Head and Neck CancerTreatment(21% oxygen vs. 1% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000380068Head and Neck CancerTreatment(21% oxygen vs 0% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000380068Hepatocellular CarcinomaNormal vs. CancertissueUp1.711866469
ENSP00000380068pancreatic ductal adenocarcinomaNormal vs. CancertissueDown17492507
ENSP00000380068Pancreatic CancerNormal vs. CancertissueUp25019357035
ENSP00000380068Pancreatic CancerNormal vs. CancertissueUp110019357035
ENSP00000380068Pancreatic CancerNormal vs. CancertissueUp130019357035
ENSP00000380068Pancreatic CancerNormal vs. CancertissueUp19357035
ENSP00000380068Pancreatic CancerTreatment (Gemcitabine-sensitive vs. Gemcitabine-resistant)cell lineDown0.4920944110

Hyperphosphorylation site
G3P_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANG3P_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANG3P_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANG3P_HUMANkinase -> substrateRobert H Newman (2013)
A4_HUMANG3P_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00010Glycolysis / Gluconeogenesis
hsa01100Metabolic pathways
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0051402neuron apoptotic processISSbiological_process
GO:0050821protein stabilizationISSbiological_process
GO:0050661NADP bindingIEAmolecular_function
GO:0005634nucleusISScellular_component
GO:0017148negative regulation of translationIMPbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0004365glyceraldehyde-3-phosphate dehydrogenase (NAD+) (pIEAmolecular_function
GO:0008017microtubule bindingISSmolecular_function
GO:0071346cellular response to interferon-gammaIDAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0016620oxidoreductase activity, acting on the aldehyde orIEAmolecular_function
GO:0035605peptidyl-cysteine S-nitrosylase activityISSmolecular_function
GO:0005811lipid particleIDAcellular_component
GO:0000226microtubule cytoskeleton organizationISSbiological_process
GO:0006094gluconeogenesisTASbiological_process
GO:0051287NAD bindingIEAmolecular_function
GO:0015630microtubule cytoskeletonISScellular_component
GO:0006006glucose metabolic processIEAbiological_process
GO:0006096glycolysisNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035606peptidyl-cysteine S-trans-nitrosylationISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0005829cytosolISScellular_component


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