| UniProt/SwissProt ID: | 2A5A_HUMAN |
| Description: | protein phosphatase 2, regulatory subunit B', alpha [Source:HGNC Symbol;Acc:9309] |
| Location: | chr1 q32.3 |
| Node attribute: | substrate; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S46 | SSQFRsQGSQA | PhosphoSitePlus | |
| S28 | GFTRKsVRKAQ | EIF2AK2 | HPRD |
| Y474 | KQNSAyNMHSI | PhosphoSitePlus | |
| S41 | KRSQGsSQFRS | PhosphoSitePlus; HPRD; phosphoELM | |
| S28 | GFTRKsVRKAQ | PhosphoSitePlus; phosphoELM; RegPhos | |
| S28 | GFTRKsVRKAQ | PKR | RegPhos |
| S42 | RSQGSsQFRSQ | PhosphoSitePlus; HPRD; phosphoELM | |
| S472 | LEKQNsAYNMH | PhosphoSitePlus; HPRD | |
| S484 | ILSNTsAE___ | PhosphoSitePlus | |
| S38 | QRQKRsQGSSQ | PhosphoSitePlus | |
| S49 | FRSQGsQAELH | PhosphoSitePlus | |
| Dephosphorylation site |
| 2A5A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000261461 | Q324K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000446035 | Q324K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000442866 | Q267K | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| 2A5A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| 2A5A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | 2A5A_HUMAN | kinase -> substrate | RegPhos |
| CDK4_HUMAN | 2A5A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| E2AK2_HUMAN | 2A5A_HUMAN | kinase -> substrate | HPRD; RegPhos |
| 2A5A_HUMAN | TAU_HUMAN | phosphatase -> substrate | HPRD |
| 2A5A_HUMAN | NOS3_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03015 | mRNA surveillance pathway |
| hsa04310 | Wnt signaling pathway |
| hsa04728 | Dopaminergic synapse |
| hsa04114 | Oocyte meiosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019900 | kinase binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0016020 | membrane | IDA | cellular_component |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0031430 | M band | ISS | cellular_component |
| GO:0000775 | chromosome, centromeric region | IEA | cellular_component |
| GO:0035307 | positive regulation of protein dephosphorylation | IMP | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0000159 | protein phosphatase type 2A complex | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0090005 | negative regulation of establishment of protein lo | IMP | biological_process |
| GO:0008601 | protein phosphatase type 2A regulator activity | IEA | molecular_function |
| GO:0090219 | negative regulation of lipid kinase activity | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |