| UniProt/SwissProt ID: | KDM4C_HUMAN |
| Description: | lysine (K)-specific demethylase 4C [Source:HGNC Symbol;Acc:17071] |
| Location: | chr9 p24.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y908 | TSQTFyEVMFD | PhosphoSitePlus | |
| S392 | EEEEVsDEVDG | PhosphoSitePlus | |
| T903 | RVMAVtSQTFY | PhosphoSitePlus | |
| T353 | PTPAStPEVKA | PhosphoSitePlus | |
| S582 | RPPARsPMTLV | PhosphoSitePlus | |
| S248 | KMTLIsPSVLK | JmjC | PhosphoSitePlus |
| T906 | AVTSQtFYEVM | PhosphoSitePlus | |
| S250 | TLISPsVLKKY | JmjC | PhosphoSitePlus |
| T1009 | MRFEDtFYGAD | PhosphoSitePlus | |
| T985 | REDIYtLDEEL | PhosphoSitePlus | |
| S916 | MFDDGsFSRDT | PhosphoSitePlus | |
| Dephosphorylation site |
| KDM4C_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000370707 | E784D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000370710 | E784D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| KDM4C_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KDM4C_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK4_HUMAN | KDM4C_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KDM4C_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0032454 | histone demethylase activity (H3-K9 specific) | IMP | molecular_function |
| GO:0019899 | enzyme binding | IEA | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | IMP | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IDA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0050681 | androgen receptor binding | IEA | molecular_function |
| GO:0046417 | chorismate metabolic process | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0016702 | oxidoreductase activity, acting on single donors w | IEA | molecular_function |
| GO:0033169 | histone H3-K9 demethylation | IMP | biological_process |
| GO:0000790 | nuclear chromatin | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0050681 | androgen receptor binding | IPI | molecular_function |