| UniProt/SwissProt ID: | MCM7_HUMAN |
| Description: | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:6950] |
| Location: | chr7 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T406 | LADYItAAYVE | HPRD | |
| Y6 | MALKDyALEKE | PhosphoSitePlus | |
| S324 | YNPRRsLEQNI | HPRD | |
| S309 | VKMNKsEDDES | PhosphoSitePlus; HPRD | |
| Y600 | SKDATyTSART | MCM | PhosphoSitePlus |
| S500 | YNPRRsLEQNI | MCM | PhosphoSitePlus; SysPTM |
| S113 | MMEQRsRDPGM | PhosphoSitePlus; HPRD | |
| S549 | SRQPPsQFEPL | MCM | PhosphoSitePlus |
| Y6 | LEKE | HPRD | |
| Y492 | AANPAyGRYNP | MCM | PhosphoSitePlus |
| T144 | GAGELtREELR | HPRD | |
| S121 | PGMVRsPQNQY | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S133 | VKMNKsEDDES | HPRD | |
| T320 | GAGELtREELR | MCM | PhosphoSitePlus |
| Y580 | ESLADyITAAY | MCM | PhosphoSitePlus |
| S678 | RSVRFsEAEQR | PhosphoSitePlus | |
| S500 | YNPRRsLEQNI | HPRD; phosphoELM; SysPTM | |
| S549 | SRQPPsQFEPL | HPRD; phosphoELM | |
| S189 | GGVDQsPRGMK | HPRD | |
| T320 | GAGELtREELR | HPRD | |
| S314 | SEDDEsGAGEL | PhosphoSitePlus | |
| S392 | KSQLLsYIDRL | MCM | PhosphoSitePlus |
| T582 | LADYItAAYVE | HPRD | |
| S373 | SRQPPsQFEPL | HPRD | |
| S365 | GGVDQsPRGMK | HPRD | |
| S365 | GGVDQsPRGMK | MCM | PhosphoSitePlus |
| Dephosphorylation site |
| MCM7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| MCM7_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000307288 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.41 | 18646787 |
| Hyperphosphorylation site |
| MCM7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DYRK2_HUMAN | MCM7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDC7_HUMAN | MCM7_HUMAN | kinase -> substrate | RegPhos |
| KS6A5_HUMAN | MCM7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | MCM7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ATR_HUMAN | MCM7_HUMAN | kinase -> substrate | RegPhos |
| ARAF_HUMAN | MCM7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | MCM7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | MCM7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | MCM7_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04110 | Cell cycle |
| hsa03030 | DNA replication |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS | biological_process |
| GO:0071364 | cellular response to epidermal growth factor stimu | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0071310 | cellular response to organic substance | IEA | biological_process |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | IDA | molecular_function |
| GO:0003697 | single-stranded DNA binding | IEA | molecular_function |
| GO:0017111 | nucleoside-triphosphatase activity | IEA | molecular_function |
| GO:0015979 | photosynthesis | IEA | biological_process |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0000785 | chromatin | TAS | cellular_component |
| GO:0016851 | magnesium chelatase activity | IEA | molecular_function |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0006268 | DNA unwinding involved in replication | IEA | biological_process |
| GO:0003678 | DNA helicase activity | IEA | molecular_function |
| GO:0015995 | chlorophyll biosynthetic process | IEA | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042555 | MCM complex | IMP | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016887 | ATPase activity | IEA | molecular_function |
| GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006260 | DNA replication | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IMP | biological_process |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0042325 | regulation of phosphorylation | IMP | biological_process |