Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZIC4_HUMAN
Description:Zic family member 4 [Source:HGNC Symbol;Acc:20393]
Location:chr3 q24
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T227KIHKRtHTGEKzf-C2H2PhosphoSitePlus
T229HKRTHtGEKPFPhosphoSitePlus

Dephosphorylation site
ZIC4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000372553V307MCOSMICHead and Neck Cancer21798893
ENSP00000372553V287MCOSMICHead and Neck Cancer21798893
ENSP00000372553F117LCOSMICHead and Neck Cancer21798897
ENSP00000372553C241WCOSMICHead and Neck Cancer21798893

Differential expressed protein
ZIC4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZIC4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CLK2_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)
VRK3_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ZIC4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008270zinc ion bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005622intracellularIEAcellular_component


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