Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M18BP_HUMAN
Description:MIS18 binding protein 1 [Source:HGNC Symbol;Acc:20190]
Location:chr14 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T821ILEPEtEESENPhosphoSitePlus; HPRD; phosphoELM
S690ECQKKsPISKSPhosphoSitePlus
Y108KNKANyESPGKPhosphoSitePlus
S824PETEEsENEFYPhosphoSitePlus; HPRD; phosphoELM
S860TEAVGsDKTNRPhosphoSitePlus; HPRD
T218PLHNLtYELPTPhosphoSitePlus
S1004RILLPsFQDSEPhosphoSitePlus; HPRD; phosphoELM
S1131FSNSDsA____PhosphoSitePlus
T1089DFSTPtPRRKTPhosphoSitePlus; HPRD; phosphoELM
T267KSKKDtFVLESPhosphoSitePlus
S1086VETDFsTPTPRPhosphoSitePlus; HPRD; phosphoELM
T339GSMKDtCKIVLPhosphoSitePlus
S299PIKNGsLLMVSPhosphoSitePlus; HPRD
S135PSRNSsLLEPQPhosphoSitePlus; HPRD
S183SSLRAsVQGVPPhosphoSitePlus
T261SIVATtKSKKDHPRD; phosphoELM
T702GTLENtFEGHKPhosphoSitePlus
S1129YYFSNsDSA__PhosphoSitePlus
S172KENNKsFQSDDPhosphoSitePlus
Y763VAMSFyKHQSSPhosphoSitePlus
S773SPDLSsEESETPhosphoSitePlus
T161KKLQHtYLCEEPhosphoSitePlus
T330TVPGEtGLPGSPhosphoSitePlus
S304SLLMVsDSERTPhosphoSitePlus
S1104DLGENsGIGKLPhosphoSitePlus; HPRD; phosphoELM
S772SSPDLsSEESEPhosphoSitePlus
S761NQVAMsFYKHQPhosphoSitePlus
T855KEFPItEAVGSHPRD
T1087ETDFStPTPRRPhosphoSitePlus; HPRD; phosphoELM
S776LSSEEsETEKEPhosphoSitePlus
S191GVPLEsSNNDIPhosphoSitePlus
S1127KDYYFsNSDSAPhosphoSitePlus
T352PRLHItIPRRSPhosphoSitePlus
S1008PSFQDsEDDDDPhosphoSitePlus; HPRD; phosphoELM
T992DDFFStTPLQHHPRD; phosphoELM
S275LESVDsADEQFPhosphoSitePlus
Y219LHNLTyELPTLPhosphoSitePlus
S110KANYEsPGKIFPhosphoSitePlus; HPRD; phosphoELM
T283EQFQNtNAETLPhosphoSitePlus
T993DFFSTtPLQHQPhosphoSitePlus; HPRD; phosphoELM
S894HCAFAsLPKHKMyb_DNA-bindingPhosphoSitePlus
S178FQSDDsSLRASPhosphoSitePlus
T523QRATTtYDFDCPhosphoSitePlus
S263VATTKsKKDTFHPRD; phosphoELM
T1098KTPFNtDLGENPhosphoSitePlus
S693KKSPIsKSMGTPhosphoSitePlus
S175NKSFQsDDSSLPhosphoSitePlus
S142LEPQKsGNNETPhosphoSitePlus
Y829SENEFyIKQKKPhosphoSitePlus
S179QSDDSsLRASVPhosphoSitePlus
T653AYILVtPLKSRPhosphoSitePlus; HPRD; phosphoELM
S634REQFFsDEERKPhosphoSitePlus
S541NKHSEsPGATEHPRD; phosphoELM
S914AVGSRsPEECQHPRD; phosphoELM
S335TGLPGsMKDTCPhosphoSitePlus
T223TYELPtLNQEQPhosphoSitePlus
T1024DKNPTtPSSVIPhosphoSitePlus; HPRD
S365NISKLsPPRIFPhosphoSitePlus; HPRD
S991HDDFFsTTPLQHPRD; phosphoELM
S192VPLESsNNDIFPhosphoSitePlus; HPRD; phosphoELM
T346KIVLAtPRLHIPhosphoSitePlus
S729RKIKIsNLEKEPhosphoSitePlus
T260ESIVAtTKSKKPhosphoSitePlus
S1116TNAVEsLDEEEPhosphoSitePlus; HPRD

Dephosphorylation site
M18BP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309790K157fs*24COSMICOvarian Cancer21720365
ENSP00000309790L885SCOSMICHepatocellular Carcinoma21822264
ENSP00000309790D861HBIOMARTBreast Cancer21930507, 21930502
ENSP00000309790A517TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
M18BP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M18BP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGFR2_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
CLK2_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
MARK2_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
M18BP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003682chromatin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0034080CENP-A containing nucleosome assembly at centromerTASbiological_process
GO:0006334nucleosome assemblyTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0007067mitosisIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0000775chromosome, centromeric regionIEAcellular_component


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