| UniProt/SwissProt ID: | RPAC1_HUMAN |
| Description: | polymerase (RNA) I polypeptide C, 30kDa [Source:HGNC Symbol;Acc:20194] |
| Location: | chr6 p21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y124 | PRLFEyRNQGD | RNA_pol_L; RNA_pol_A_bac | PhosphoSitePlus |
| Y33 | DFPGNySGYDD | PhosphoSitePlus; HPRD; phosphoELM | |
| S4 | __MAAsQAVEE | PhosphoSitePlus | |
| S254 | AAEELsRCFSP | HPRD | |
| T282 | NPRLDtFSREI | RNA_pol_L | PhosphoSitePlus |
| S34 | FPGNYsGYDDA | PhosphoSitePlus | |
| S226 | DHAKFsPVATA | HPRD | |
| Y36 | GNYSGyDDAWD | PhosphoSitePlus | |
| S284 | RLDTFsREIFR | RNA_pol_L | PhosphoSitePlus |
| Dephosphorylation site |
| RPAC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361465 | *347C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361465 | *347S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RPAC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RPAC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CLK2_HUMAN | RPAC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGR_HUMAN | RPAC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RPAC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | RPAC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RPAC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0006360 | transcription from RNA polymerase I promoter | TAS | biological_process |
| GO:0006386 | termination of RNA polymerase III transcription | TAS | biological_process |
| GO:0005736 | DNA-directed RNA polymerase I complex | TAS | cellular_component |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006363 | termination of RNA polymerase I transcription | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003899 | DNA-directed RNA polymerase activity | IEA | molecular_function |
| GO:0006385 | transcription elongation from RNA polymerase III p | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006361 | transcription initiation from RNA polymerase I pro | TAS | biological_process |
| GO:0006362 | transcription elongation from RNA polymerase I pro | TAS | biological_process |
| GO:0006383 | transcription from RNA polymerase III promoter | TAS | biological_process |