Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TAB1_HUMAN
Description:TGF-beta activated kinase 1/MAP3K7 binding protein 1 [Source:HGNC Symbol;Acc:18157]
Location:chr22 q13.1
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S438TLTNQsPTLTLp38a(MAPK14RegPhos
S453THTQSsSSSSDPhosphoSitePlus
T185VANVGtNRALLPP2CPhosphoSitePlus
S456QSSSSsSDGGLPhosphoSitePlus
S423VNGAHsASTLDMAPK14phosphoELM
S438TLTNQsPTLTLPhosphoSitePlus
S378SQPTPsPAPAAPhosphoSitePlus
S7LQSEHPRD; phosphoELM; SysPTM
Y179LNNKLyVANVGPP2CPhosphoSitePlus
T431TLDEAtPTLTNp38a(MAPK14RegPhos
T431TLDEAtPTLTNMAPK14phosphoELM
Y481GRVEPyVDFAEPhosphoSitePlus
S11RSLLQsEQQPSPhosphoSitePlus
S423VNGAHsASTLDp38a(MAPK14RegPhos
S16SEQQPsWTDDLPhosphoSitePlus
S457SSSSSsDGGLFPhosphoSitePlus
T431TLDEAtPTLTNPhosphoSitePlus
S7AAQRRsLLQSEPhosphoSitePlus; SysPTM
S452NTHTQsSSSSSPhosphoSitePlus
Y488DFAEFyRLWSVPhosphoSitePlus
S438TLTNQsPTLTLMAPK14phosphoELM
S423VNGAHsASTLDPhosphoSitePlus

Dephosphorylation site
TAB1_HUMAN do not have dephosphorylation site.

Mutation site
TAB1_HUMAN do not have mutation site.

Differential expressed protein
TAB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TAB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANTAB1_HUMANkinase -> substrateRobert H Newman (2013)
IL1R1_HUMANTAB1_HUMANotherKEGG
TNR1A_HUMANTAB1_HUMANotherKEGG
TAB1_HUMANM3K7_HUMANotherKEGG
CD14_HUMANTAB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa05145Toxoplasmosis
hsa05169Epstein-Barr virus infection
hsa04621NOD-like receptor signaling pathway
hsa05140Leishmaniasis
hsa04064NF-kappa B signaling pathway
hsa05168Herpes simplex infection
hsa04620Toll-like receptor signaling pathway
hsa04380Osteoclast differentiation

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008047enzyme activator activityTASmolecular_function
GO:0000187activation of MAPK activityTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0003007heart morphogenesisIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0019209kinase activator activityIEAmolecular_function
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000185activation of MAPKKK activityIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0030324lung developmentIEAbiological_process


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