Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SL9A1_HUMAN
Description:solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 [Source:HGNC Symbol;Acc:11071]
Location:chr1 p36.11
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S726PASPQsPESVDPhosphoSitePlus; phosphoELM
T718DLPVItIDPASp38aRegPhos
S770RSKETsSPGTDErk2RegPhos
S729PQSPEsVDLVNp38a(MAPK14RegPhos
S785PAPSDsPSSQRErk2RegPhos; SysPTM
S703RARIGsDPLAYRSK_groupphosphoELM; RegPhos; SysPTM
S726PASPQsPESVDp38aRegPhos
S605AVSTVsMQNIHRegPhos
T779TDDVFtPAPSDErk2RegPhos
T603PSAVStVSMQNToprim_3PhosphoSitePlus
S605AVSTVsMQNIHToprim_3PhosphoSitePlus
S771SKETSsPGTDDPhosphoSitePlus; HPRD; phosphoELM
S158PPFLQsDVFFLTM; Na_H_ExchangerPhosphoSitePlus
S788SDSPSsQRIQRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y659LVADPyEEAWNToprim_3PhosphoSitePlus
T718DLPVItIDPASPhosphoSitePlus
S729PQSPEsVDLVNPhosphoSitePlus; phosphoELM
S693AHKLDsPTMSRMAPK1HPRD
Y708SDPLAyEPKEDPhosphoSitePlus
S785PAPSDsPSSQRPhosphoSitePlus; phosphoELM; SysPTM
Y577QLIAFyHKMEMPhosphoSitePlus
S723TIDPAsPQSPEPhosphoSitePlus; phosphoELM
T718DLPVItIDPASMAPK14HPRD; phosphoELM
S599MGKIPsAVSTVToprim_3PhosphoSitePlus
S648RQRLRsYNRHTToprim_3PhosphoSitePlus
T779TDDVFtPAPSDMAPK1HPRD
T779TDDVFtPAPSDPhosphoSitePlus
S770RSKETsSPGTDPhosphoSitePlus; phosphoELM
S770RSKETsSPGTDMAPK1HPRD
S796IQRCLsDPGPHPhosphoSitePlus
S766GIMMRsKETSSErk2RegPhos
S602IPSAVsTVSMQRegPhos
S729PQSPEsVDLVNMAPK14HPRD; phosphoELM
T718DLPVItIDPASp38a(MAPK14RegPhos
S726PASPQsPESVDMAPK14HPRD; phosphoELM
S602IPSAVsTVSMQToprim_3PhosphoSitePlus
S693AHKLDsPTMSRErk2RegPhos
S723TIDPAsPQSPEp38a(MAPK14RegPhos
S766GIMMRsKETSSMAPK1HPRD
S599MGKIPsAVSTVRegPhos
Y683QKINNyLTVPAPhosphoSitePlus; HPRD; SysPTM
T42LQLSPtASTIRPhosphoSitePlus
S723TIDPAsPQSPEp38aRegPhos
S726PASPQsPESVDp38a(MAPK14RegPhos
S693AHKLDsPTMSRPhosphoSitePlus; phosphoELM; RegPhos
S723TIDPAsPQSPEMAPK14HPRD; phosphoELM
T695KLDSPtMSRARPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T685INNYLtVPAHKPhosphoSitePlus
S785PAPSDsPSSQRMAPK1HPRD; SysPTM
S787PSDSPsSQRIQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S783FTPAPsDSPSSPhosphoSitePlus; HPRD; phosphoELM
S729PQSPEsVDLVNp38aRegPhos
S703RARIGsDPLAYPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S697DSPTMsRARIGPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
SL9A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363199*556CCOSMICOvarian Cancer21720365
ENSP00000263980P772SCOSMICSkin Cancer21984974
ENSP00000263980Q449*COSMICSkin Cancer21984974
ENSP00000263980L336FCOSMICCentral Nervous System Neoplasms18772396
ENSP00000263980E735*COSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000263980Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
SL9A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ROCK1_HUMANSL9A1_HUMANkinase -> substrateKEGG
MK14_HUMANSL9A1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANSL9A1_HUMANkinase -> substrateRegPhos
MK01_HUMANSL9A1_HUMANkinase -> substrateHPRD
SL9A1_HUMANARPC5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04260Cardiac muscle contraction
hsa04972Pancreatic secretion
hsa04970Salivary secretion
hsa04976Bile secretion
hsa04971Gastric acid secretion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006885regulation of pHTASbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0006812cation transportIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0006814sodium ion transportIEAbiological_process
GO:0051453regulation of intracellular pHIDAbiological_process
GO:0016021integral to membraneTAScellular_component
GO:0030203glycosaminoglycan metabolic processTASbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:0051930regulation of sensory perception of painIEAbiological_process
GO:0071436sodium ion exportISSbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0071468cellular response to acidityISSbiological_process
GO:0001101response to acidIDAbiological_process
GO:0015299solute:hydrogen antiporter activityTASmolecular_function
GO:0070997neuron deathIEAbiological_process
GO:0030212hyaluronan metabolic processTASbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0010740positive regulation of intracellular protein kinasIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0010447response to acidityIEAbiological_process
GO:0051259protein oligomerizationISSbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0010447response to acidityIDAbiological_process
GO:0015385sodium:hydrogen antiporter activityISSmolecular_function
GO:0001101response to acidIEAbiological_process
GO:0006885regulation of pHIEAbiological_process
GO:0030307positive regulation of cell growthIEAbiological_process
GO:0055007cardiac muscle cell differentiationIEAbiological_process
GO:0006811ion transportTASbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0045760positive regulation of action potentialIEAbiological_process
GO:0048306calcium-dependent protein bindingIDAmolecular_function
GO:0002026regulation of the force of heart contractionIEAbiological_process
GO:0035794positive regulation of mitochondrial membrane permIEAbiological_process
GO:0030214hyaluronan catabolic processTASbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0016049cell growthIEAbiological_process
GO:0005783endoplasmic reticulumISScellular_component
GO:0015385sodium:hydrogen antiporter activityIEAmolecular_function
GO:0055085transmembrane transportTASbiological_process


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