Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAK6_HUMAN
Description:p21 protein (Cdc42/Rac)-activated kinase 6 [Source:HGNC Symbol;Acc:16061]
Location:chr15 q15.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S113RRRAQsLGLLGPhosphoSitePlus
T564KSLVGtPYWMAPkinasePhosphoSitePlus
Y566LVGTPyWMAPEPkinasePhosphoSitePlus
S179AAKAQsLGPAEPhosphoSitePlus; HPRD
Y566LVGTPyWMAPEMAP2K6phosphoELM; RegPhos
S560VPKRKsLVGTPPkinasePhosphoSitePlus
Y81MPVDGyISGLLPhosphoSitePlus
S165WPEPQsPRVLPMAPK14phosphoELM
S135LQSPQsERTDPPhosphoSitePlus
Y365STSNLyLPQDPPhosphoSitePlus
T371LPQDPtVAKGAPhosphoSitePlus
Y144DPHGLyLSCNGPhosphoSitePlus
S560VPKRKsLVGTPHPRD; phosphoELM; RegPhos
T339RTAPAtGQLPGPhosphoSitePlus
T564KSLVGtPYWMAMAP2K6phosphoELM; RegPhos
S132DMYLQsPQSERPhosphoSitePlus
S83VDGYIsGLLNDPhosphoSitePlus
S165WPEPQsPRVLPp38a(MAPK14RegPhos
Y129TDPDMyLQSPQPhosphoSitePlus
S104TLRGRsPTSRRPhosphoSitePlus
S165WPEPQsPRVLPPhosphoSitePlus
S207SPPGAsPPTGTPhosphoSitePlus

Dephosphorylation site
PAK6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000260404R3HSjoblom2006Intestines Cancer16959974
ENSP00000453858R497STCGAOvarian Cancer21720365, 18772890
ENSP00000406873L514RHPISmall cell lung carcinoma17344846
ENSP00000439597R497STCGAOvarian Cancer21720365, 18772890
ENSP00000406873R3HBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000260404R3HHPIColorectal Cancer16959974
ENSP00000401153L514RHPISmall cell lung carcinoma17344846
ENSP00000401153R497STCGAOvarian Cancer21720365, 18772890
ENSP00000260404R497STCGAOvarian Cancer21720365, 18772890
ENSP00000406873R497STCGAOvarian Cancer21720365, 18772890
ENSP00000401153R3HHPIColorectal Cancer16959974
ENSP00000260404L514RHPISmall cell lung carcinoma17344846
ENSP00000260404L514RGreenman2007Lung Cancer17344846, 18428421
ENSP00000260404V627IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
PAK6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PAK6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PAK6_HUMANPSPC1_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANSART3_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANPAK6_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANTIF1A_HUMANkinase -> substrateRobert H Newman (2013)
PAK6_HUMANANDR_HUMANkinase -> substrateNetPath
ZAGL2_HUMANPAK6_HUMANkinase -> substrateRegPhos
MP2K6_HUMANPAK6_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PAK6_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04810Regulation of actin cytoskeleton
hsa04360Axon guidance
hsa04012ErbB signaling pathway
hsa05211Renal cell carcinoma
hsa04510Focal adhesion
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007010cytoskeleton organizationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0005634nucleusIEAcellular_component