Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFH_HUMAN
Description:neurofilament, heavy polypeptide [Source:HGNC Symbol;Acc:7737]
Location:chr22 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S580PAEVKsPEKAKDUF1388PhosphoSitePlus
S61SSVSAsPSRFRPhosphoSitePlus; RegPhos
S696KAEAKsPEKAKDUF1388; DUF1388PhosphoSitePlus
S546PAEVKsPEKAKRegPhos
S511AEEAAsPEKEADUF1388PhosphoSitePlus
S674PEKAKsPVKAEDUF1388; DUF1388PhosphoSitePlus
S540KEEAKsPAEVKDUF1388PhosphoSitePlus
S552PEKAKsPAKEEDUF1388PhosphoSitePlus
S782KEEARsPADKFPhosphoSitePlus
S801KEEVKsPEKAKphosphoELM; RegPhos
T738KEEAKtPEKAKDUF1388PhosphoSitePlus
S634PAEVKsPEKAKHPRD; RegPhos
S628KEEAKsPAEVKHPRD; RegPhos
S710KEEAKsPEKAKRegPhos
S763TLDVKsPEAKTHPRD
S682KAEAKsPEKAKRegPhos
S606PEKAKsPVKEEDUF1388PhosphoSitePlus
S574KEEAKsPAEVKDUF1388PhosphoSitePlus
S758PEKAKsPEKAKDUF1388PhosphoSitePlus
S532PAEAKsPEKEEDUF1388PhosphoSitePlus
S660PEKAKsPEKEERegPhos
S518EKEAKsPVKEEMAPK1HPRD
S648KEEAKsPEEAKRegPhos
S948KAKEPsKPAEKPhosphoSitePlus
S511AEEAAsPEKEAHPRD
S526KEEAKsPAEAKMAPK1HPRD
S640PEKAKsPTKEEDUF1388PhosphoSitePlus
S676KAEAKsPEKAKHPRD
S546PAEVKsPEKAKDUF1388PhosphoSitePlus
S660PEKAKsPEKEEDUF1388PhosphoSitePlus
S682KAEAKsPEKAKDUF1388PhosphoSitePlus
S620PAEAKsPVKEEHPRD; RegPhos
S668KEEAKsPEKAKDUF1388; DUF1388PhosphoSitePlus
S614KEEAKsPAEAKDUF1388PhosphoSitePlus
S540KEEAKsPAEVKRegPhos
S828KEEVKsPVKEEPhosphoSitePlus; RegPhos
S668PEKAKsPVKAEHPRD
S532PAEAKsPEKEERegPhos
S566PPEAKsPEKEERegPhos
S648KEEAKsPEKAKHPRD
S787PEKAKsPVKEEHPRD
S724PEKAKsPVKEEHPRD
S518EKEAKsPVKEEDUF1388PhosphoSitePlus
S606PEKAKsPVKEERegPhos
S594KEEAKsPAEAKDUF1388; DUF1388PhosphoSitePlus
S716PEKAKsPVKEEDUF1388; DUF1388PhosphoSitePlus
S560KEEAKsPPEAKRegPhos
S560KEEAKsPPEAKDUF1388; DUF1388PhosphoSitePlus
S746KEEAKsPEKAKHPRD
S801KEEVKsPEKAKDUF1388PhosphoSitePlus
S822KEEVKsPVKEEHPRD
S702PEKAKsPVKEERegPhos
S724KEEAKsPEKAKRegPhos
S724KEEAKsPEKAKDUF1388; DUF1388PhosphoSitePlus
S574KEEAKsPAEVKRegPhos
S59SVSSVsASPSRPhosphoSitePlus
S620PAEAKsPVKEEDUF1388; DUF1388PhosphoSitePlus
S730PEKAKsPVKEEDUF1388; DUF1388PhosphoSitePlus
S696KAEAKsPEKAKRegPhos
Y111DRFAGyIDKVRFilamentPhosphoSitePlus
S532PAEAKsPEKEEErk2RegPhos
S654PEKAKsPEKAKDUF1388PhosphoSitePlus
S795KEEVKsPEKAKHPRD
S793PEKAKsPVKEEDUF1388PhosphoSitePlus
S993LSKEPsKPKAEPhosphoSitePlus
S337LEALKsTKDSLFilament; Gp58PhosphoSitePlus
Y385AQLREyQDLLNFilament; Gp58PhosphoSitePlus
S526KEEAKsPAEAKErk2RegPhos
S526KEEAKsPAEAKDUF1388PhosphoSitePlus
S710KEEAKsPEKAKDUF1388; DUF1388PhosphoSitePlus
S634PAEVKsPEKAKDUF1388PhosphoSitePlus
S526KEEAKsPAEAKRegPhos
S600PAEAKsPEKAKRegPhos
S566PPEAKsPEKEEDUF1388PhosphoSitePlus
S662KEEAKsPEKAKHPRD
T774SPEAKtPAKEERegPhos
S688PEKAKsPVKAEDUF1388PhosphoSitePlus
S600PAEAKsPEKAKDUF1388PhosphoSitePlus
S628KEEAKsPAEVKDUF1388PhosphoSitePlus
S640PEKAKsPTKEEHPRD; RegPhos
S532PAEAKsPEKEEMAPK1HPRD
S63VSASPsRFRGAPhosphoSitePlus
S518EKEAKsPVKEEErk2RegPhos
S668KEEAKsPEKAKRegPhos
S688PEKAKsPVKAERegPhos
T732KEEAKtPEKAKHPRD
S654PEKAKsPEKEEHPRD
T911KKKVPtPEKEAPhosphoSitePlus
S769TLDVKsPEAKTPhosphoSitePlus; RegPhos
S793PEKAKsPVKEEphosphoELM; RegPhos
S702PEKAKsPVKEEDUF1388; DUF1388PhosphoSitePlus
S752PEKAKsPEKAKHPRD
S503EEETKsPPAEEPhosphoSitePlus; HPRD; RegPhos
S614KEEAKsPAEAKHPRD; RegPhos
T501GGEEEtKSPPAPhosphoSitePlus; HPRD; RegPhos
S654PEEAKsPEKAKRegPhos
S752KEEAKsPEKAKDUF1388PhosphoSitePlus
S552PEKAKsPAKEERegPhos
S648KEEAKsPEKAKDUF1388PhosphoSitePlus
S744PEKAKsPVKEEDUF1388PhosphoSitePlus
S674PEKAKsPVKAERegPhos

Dephosphorylation site
NFH_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000311997S359TCOSMICOvarian Cancer21720365

Differential expressed protein
NFH_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S801DUF1388PVKEEVKsPEKAKSPAlzheimer's disease20624930PhosphoSitePlus
S716DUF1388; DUF1388KSPEKAKsPVKEEAKAlzheimer's disease20624930PhosphoSitePlus
S648DUF1388PTKEEAKsPEKAKSPAlzheimer's disease20624930PhosphoSitePlus
S744DUF1388KTPEKAKsPVKEEAKAlzheimer's disease20624930PhosphoSitePlus
S640DUF1388KSPEKAKsPTKEEAKAlzheimer's disease20624930PhosphoSitePlus
S546DUF1388KSPAEVKsPEKAKSPAlzheimer's disease20624930PhosphoSitePlus
S710DUF1388; DUF1388PVKEEAKsPEKAKSPAlzheimer's disease20624930PhosphoSitePlus
S580DUF1388KSPAEVKsPEKAKSPAlzheimer's disease20624930PhosphoSitePlus
S702DUF1388; DUF1388KSPEKAKsPVKEEAKAlzheimer's disease20624930PhosphoSitePlus
S620DUF1388; DUF1388KSPAEAKsPVKEEAKAlzheimer's disease20624930PhosphoSitePlus
S948DAKAKEPsKPAEKKEAlzheimer's disease21828286PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNFH_HUMANkinase -> substrateRegPhos
MK14_HUMANNFH_HUMANkinase -> substrateKEGG
MK01_HUMANNFH_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045110intermediate filament bundle assemblyIEAbiological_process
GO:0060052neurofilament cytoskeleton organizationIEAbiological_process
GO:0005883neurofilamentNAScellular_component
GO:0007399nervous system developmentNASbiological_process
GO:0003674molecular_functionNDmolecular_function
GO:0008219cell deathIEAbiological_process
GO:0005883neurofilamentIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0045104intermediate filament cytoskeleton organizationIEAbiological_process
GO:0030424axonTAScellular_component