Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ELK4_HUMAN
Description:ELK4, ETS-domain protein (SRF accessory protein 1) [Source:HGNC Symbol;Acc:3326]
Location:chr1 q32.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S180LAEKKsPQEPTPhosphoSitePlus
T185SPQEPtPSVIKPhosphoSitePlus
T420LDGPStPGPFSPhosphoSitePlus
S381FWSTLsPVAPLPhosphoSitePlus
S425TPGPFsPDLQKPhosphoSitePlus
S230LETLVsPKLPSPhosphoSitePlus
T135QPGAKtSSRNDPhosphoSitePlus
S419GLDGPsTPGPFPhosphoSitePlus
S387PVAPLsPARLQPhosphoSitePlus
S215IGPSIsPSSEEPhosphoSitePlus; HPRD

Dephosphorylation site
ELK4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000289703N383TBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000350681P231QBIOMARTBreast Cancer21930507, 21930502
ENSP00000289703P231QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
ELK4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ELK4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANELK4_HUMANkinase -> substrateKEGG
MK14_HUMANELK4_HUMANkinase -> substrateKEGG
ELK4_HUMANACTB_HUMANTF -> target geneTRANSFAC
ELK4_HUMANFOS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05166HTLV-I infection
hsa05202Transcriptional misregulation in cancer
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0003677DNA bindingTASmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0070932histone H3 deacetylationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001047core promoter bindingTASmolecular_function
GO:0003682chromatin bindingIDAmolecular_function
GO:0003712transcription cofactor activityTASmolecular_function
GO:0000122negative regulation of transcription from RNA polyIMPbiological_process


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