| UniProt/SwissProt ID: | ELK4_HUMAN |
| Description: | ELK4, ETS-domain protein (SRF accessory protein 1) [Source:HGNC Symbol;Acc:3326] |
| Location: | chr1 q32.1 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S180 | LAEKKsPQEPT | PhosphoSitePlus | |
| T185 | SPQEPtPSVIK | PhosphoSitePlus | |
| T420 | LDGPStPGPFS | PhosphoSitePlus | |
| S381 | FWSTLsPVAPL | PhosphoSitePlus | |
| S425 | TPGPFsPDLQK | PhosphoSitePlus | |
| S230 | LETLVsPKLPS | PhosphoSitePlus | |
| T135 | QPGAKtSSRND | PhosphoSitePlus | |
| S419 | GLDGPsTPGPF | PhosphoSitePlus | |
| S387 | PVAPLsPARLQ | PhosphoSitePlus | |
| S215 | IGPSIsPSSEE | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| ELK4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000289703 | N383T | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000350681 | P231Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000289703 | P231Q | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ELK4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ELK4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | ELK4_HUMAN | kinase -> substrate | KEGG |
| MK14_HUMAN | ELK4_HUMAN | kinase -> substrate | KEGG |
| ELK4_HUMAN | ACTB_HUMAN | TF -> target gene | TRANSFAC |
| ELK4_HUMAN | FOS_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0070932 | histone H3 deacetylation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0001047 | core promoter binding | TAS | molecular_function |
| GO:0003682 | chromatin binding | IDA | molecular_function |
| GO:0003712 | transcription cofactor activity | TAS | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IMP | biological_process |