Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASP8_HUMAN
Description:caspase 8, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1509]
Location:chr2 q33.1
Node attribute:PPI(target); cleavage(source); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S230VYQMKsKPRGYHPRD
S347GLKCPsLAGKPp38a(MAPK14RegPhos
S375PVETDsEEQPYPeptidase_C14PhosphoSitePlus
S289VYQMKsKPRGYHPRD
T373GIPVEtDSEEQPeptidase_C14PhosphoSitePlus
S347GLKCPsLAGKPPeptidase_C14PhosphoSitePlus
S276PREQDsESQTLHPRD
Y334QEAPIyELTSQPeptidase_C14PhosphoSitePlus
Y235SKPRGyCLIINPeptidase_C14PhosphoSitePlus
S219EQDSEsQTLDKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S247VYQMKsKPRGYHPRD
S217PREQDsESQTLHPRD
Y380SEEQPyLEMDLPeptidase_C14PhosphoSitePlus
S211MTISDsPREQDPhosphoSitePlus
Y334QEAPIyELTSQphosphoELM; RegPhos
S278EQDSEsQTLDKHPRD
S209GVMTIsDSPREPhosphoSitePlus
S188KERSSsLEGSPRegPhos
S215VYQMKsKPRGYHPRD
Y448LTEVNyEVSNKPeptidase_C14PhosphoSitePlus
S202PREQDsESQTLHPRD
S234PREQDsESQTLHPRD
S347GLKCPsLAGKPMAPK14phosphoELM
T263RDRNGtHLDAGPeptidase_C14PhosphoSitePlus
S204EQDSEsQTLDKHPRD
S387EMDLSsPQTRYPeptidase_C14PhosphoSitePlus
S236EQDSEsQTLDKHPRD

Dephosphorylation site
CASP8_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264275Q482*BIOMARTBreast Cancer21930507, 21930502
ENSP00000325722Q324*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264275G11RCOSMICHead and Neck Cancer21798897
ENSP00000264275F291CCOSMICHead and Neck Cancer21984974
ENSP00000376087E195*BIOMARTBreast Cancer21930507, 21930502
ENSP00000325722Q450*BIOMARTBreast Cancer21930507, 21930502
ENSP00000376091Q324*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264275E89*COSMICHead and Neck Cancer21798893
ENSP00000264275S403*COSMICHead and Neck Cancer21798893
ENSP00000376091Q450*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264275L360FCOSMICBreast Cancer20668451
ENSP00000264275S392*COSMICHead and Neck Cancer21798893
ENSP00000264274Q255*BIOMARTBreast Cancer21930507, 21930502
ENSP00000412523Q465*BIOMARTBreast Cancer21930507, 21930502
ENSP00000351273E254*BIOMARTBreast Cancer21930507, 21930502
ENSP00000351273Q524*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264275Q356*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264275L137HCOSMICHead and Neck Cancer21798893
ENSP00000351273Q398*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264274Q381*BIOMARTBreast Cancer21930507, 21930502
ENSP00000376088E195*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264275S355FCOSMICHead and Neck Cancer
ENSP00000412523E195*BIOMARTBreast Cancer21930507, 21930502
ENSP00000412523Q339*BIOMARTBreast Cancer21930507, 21930502
ENSP00000264275P405SCOSMICMelanoma

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000351273Uterine CancerTreatment(none vs. 5-Fluorouracil treatment)cell lineUp15585135

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S387Peptidase_C14YLEMDLSsPQTRYIPbreast ductal carcinoma20937773PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCASP8_HUMANkinase -> substrateRegPhos
MK14_HUMANCASP8_HUMANkinase -> substrateRobert H Newman (2013)
CASP8_HUMANM3K14_HUMANcleavageNetPath
CASP8_HUMANTRAF1_HUMANcleavageNetPath
CASP8_HUMANRIPK1_HUMANcleavageNetPath
CASP8_HUMANBID_HUMANotherNetPath
CASP8_HUMANANDR_HUMANotherNetPath
FADD_HUMANCASP8_HUMANotherKEGG
TR10B_HUMANCASP8_HUMANotherKEGG
CASP8_HUMANCASP3_HUMANotherKEGG
CASP8_HUMANBID_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04622RIG-I-like receptor signaling pathway
hsa04115p53 signaling pathway
hsa05168Herpes simplex infection
hsa05416Viral myocarditis
hsa04620Toll-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04210Apoptosis
hsa05200Pathways in cancer
hsa05145Toxoplasmosis
hsa05010Alzheimer's disease
hsa05203Viral carcinogenesis
hsa04621NOD-like receptor signaling pathway
hsa05152Tuberculosis
hsa05016Huntington's disease
hsa05134Legionellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005856cytoskeletonTAScellular_component
GO:0005739mitochondrionIDAcellular_component
GO:0001841neural tube formationIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityTASbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0031264death-inducing signaling complexIDAcellular_component
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0097191extrinsic apoptotic signaling pathwayIDAbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0007507heart developmentIEAbiological_process
GO:0030690Noc1p-Noc2p complexIEAcellular_component
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0031265CD95 death-inducing signaling complexIEAcellular_component
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0097190apoptotic signaling pathwayIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0046677response to antibioticIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0005741mitochondrial outer membraneTAScellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045471response to ethanolIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0004197cysteine-type endopeptidase activityIEAmolecular_function
GO:0009409response to coldIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0032025response to cobalt ionIEAbiological_process
GO:0045651positive regulation of macrophage differentiationIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0001525angiogenesisIEAbiological_process
GO:0051291protein heterooligomerizationIEAbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0005164tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0044297cell bodyIEAcellular_component
GO:0008234cysteine-type peptidase activityTASmolecular_function
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0034612response to tumor necrosis factorIMPbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0051603proteolysis involved in cellular protein catabolicIMPbiological_process
GO:0030225macrophage differentiationIEAbiological_process
GO:0006915apoptotic processIGIbiological_process