Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EEA1_HUMAN
Description:early endosome antigen 1 [Source:HGNC Symbol;Acc:3185]
Location:chr12 q22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T301SVNELtQKNQTTMF_DNA_bdPhosphoSitePlus
S1265SQRRVsELEKQPhosphoSitePlus
S356SRLSAsETSLHPhosphoSitePlus
S70DAGNDsGHGGEPhosphoSitePlus; HPRD
T1252NENLGtVKKEWPhosphoSitePlus
T1392AKNALtPSSKKMAPK14HPRD
T836NNRIQtTVTELPhosphoSitePlus; HPRD
T1159SIKEItNLKDAPhosphoSitePlus
T853KEALMtELSTVPhosphoSitePlus
T621VLSLEtSVNELIFT57PhosphoSitePlus
S628VNELNsQLNESIFT57PhosphoSitePlus
Y105KEEKWySEELKPhosphoSitePlus
T1392AKNALtPSSKKIBR; FYVEPhosphoSitePlus
S856LMTELsTVKDKPhosphoSitePlus
T761QRQLNtDLELRPhosphoSitePlus; HPRD
S296QKLKSsVNELTTMF_DNA_bdPhosphoSitePlus
S863VKDKLsKVSDSPhosphoSitePlus
S295LQKLKsSVNELTMF_DNA_bdPhosphoSitePlus
T908VQMENtLKEQKPhosphoSitePlus
S15PGRVGsQGSDLPhosphoSitePlus; HPRD
T839IQTTVtELQKVPhosphoSitePlus
T837NRIQTtVTELQPhosphoSitePlus; HPRD

Dephosphorylation site
EEA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000317955Q508*COSMICSkin Cancer21984974
ENSP00000317955L1063FCOSMICHead and Neck Cancer21798893
ENSP00000317955E568KCOSMICMelanoma21499247
ENSP00000317955R516HCOSMICHead and Neck Cancer21798893
ENSP00000317955L460FCOSMICHead and Neck Cancer21798893
ENSP00000317955I1195TCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000317955Ovarian CancerMetastasiscell lineDown17892554

Hyperphosphorylation site
EEA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANEEA1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05152Tuberculosis
hsa04145Phagosome
hsa04144Endocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005768endosomeIEAcellular_component
GO:0005829cytosolIDAcellular_component
GO:0005516calmodulin bindingNASmolecular_function
GO:0016189synaptic vesicle to endosome fusionTASbiological_process
GO:0005969serine-pyruvate aminotransferase complexIEAcellular_component
GO:0005769early endosomeIDAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0055037recycling endosomeIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0019897extrinsic to plasma membraneIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0008270zinc ion bindingTASmolecular_function
GO:00055451-phosphatidylinositol bindingIDAmolecular_function
GO:0006897endocytosisIMPbiological_process
GO:0031901early endosome membraneIEAcellular_component
GO:0030742GTP-dependent protein bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006906vesicle fusionIMPbiological_process
GO:0045022early endosome to late endosome transportNASbiological_process
GO:0016020membraneTAScellular_component


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