| UniProt/SwissProt ID: | EEA1_HUMAN |
| Description: | early endosome antigen 1 [Source:HGNC Symbol;Acc:3185] |
| Location: | chr12 q22 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T301 | SVNELtQKNQT | TMF_DNA_bd | PhosphoSitePlus |
| S1265 | SQRRVsELEKQ | PhosphoSitePlus | |
| S356 | SRLSAsETSLH | PhosphoSitePlus | |
| S70 | DAGNDsGHGGE | PhosphoSitePlus; HPRD | |
| T1252 | NENLGtVKKEW | PhosphoSitePlus | |
| T1392 | AKNALtPSSKK | MAPK14 | HPRD |
| T836 | NNRIQtTVTEL | PhosphoSitePlus; HPRD | |
| T1159 | SIKEItNLKDA | PhosphoSitePlus | |
| T853 | KEALMtELSTV | PhosphoSitePlus | |
| T621 | VLSLEtSVNEL | IFT57 | PhosphoSitePlus |
| S628 | VNELNsQLNES | IFT57 | PhosphoSitePlus |
| Y105 | KEEKWySEELK | PhosphoSitePlus | |
| T1392 | AKNALtPSSKK | IBR; FYVE | PhosphoSitePlus |
| S856 | LMTELsTVKDK | PhosphoSitePlus | |
| T761 | QRQLNtDLELR | PhosphoSitePlus; HPRD | |
| S296 | QKLKSsVNELT | TMF_DNA_bd | PhosphoSitePlus |
| S863 | VKDKLsKVSDS | PhosphoSitePlus | |
| S295 | LQKLKsSVNEL | TMF_DNA_bd | PhosphoSitePlus |
| T908 | VQMENtLKEQK | PhosphoSitePlus | |
| S15 | PGRVGsQGSDL | PhosphoSitePlus; HPRD | |
| T839 | IQTTVtELQKV | PhosphoSitePlus | |
| T837 | NRIQTtVTELQ | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| EEA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000317955 | Q508* | COSMIC | Skin Cancer | 21984974 | ENSP00000317955 | L1063F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000317955 | E568K | COSMIC | Melanoma | 21499247 | ENSP00000317955 | R516H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000317955 | L460F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000317955 | I1195T | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000317955 | Ovarian Cancer | Metastasis | cell line | Down | 17892554 | |
| Hyperphosphorylation site |
| EEA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK14_HUMAN | EEA1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05152 | Tuberculosis |
| hsa04145 | Phagosome |
| hsa04144 | Endocytosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005768 | endosome | IEA | cellular_component |
| GO:0005829 | cytosol | IDA | cellular_component |
| GO:0005516 | calmodulin binding | NAS | molecular_function |
| GO:0016189 | synaptic vesicle to endosome fusion | TAS | biological_process |
| GO:0005969 | serine-pyruvate aminotransferase complex | IEA | cellular_component |
| GO:0005769 | early endosome | IDA | cellular_component |
| GO:0042803 | protein homodimerization activity | IDA | molecular_function |
| GO:0055037 | recycling endosome | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019897 | extrinsic to plasma membrane | IDA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | TAS | molecular_function |
| GO:0005545 | 1-phosphatidylinositol binding | IDA | molecular_function |
| GO:0006897 | endocytosis | IMP | biological_process |
| GO:0031901 | early endosome membrane | IEA | cellular_component |
| GO:0030742 | GTP-dependent protein binding | IDA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006906 | vesicle fusion | IMP | biological_process |
| GO:0045022 | early endosome to late endosome transport | NAS | biological_process |
| GO:0016020 | membrane | TAS | cellular_component |