Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRGC1_HUMAN
Description:peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [Source:HGNC Symbol;Acc:9237]
Location:chr4 p15.2
Node attribute:PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T299LTPPTtPPHKAp38a(MAPK14RegPhos
S266PLTPEsPNDPKMAPK14HPRD; phosphoELM
Y722YGFITyRYTCDRRM_1PhosphoSitePlus
S417NKDVSsDWQGQPhosphoSitePlus
S616RTHRNsPLYVRPhosphoSitePlus
S768DLDSNsDDFDPPhosphoSitePlus
S266PLTPEsPNDPKp38aRegPhos
S416ENKDVsSDWQGPhosphoSitePlus
S782KSKYDsLDFDSPhosphoSitePlus
T263LSLPLtPESPNp38a(MAPK14RegPhos
S636RPRYDsYEEYQPhosphoSitePlus
T263LSLPLtPESPNp38aRegPhos
S208QRRPCsELLKYPhosphoSitePlus
T299LTPPTtPPHKAp38aRegPhos
T263LSLPLtPESPNMAPK14HPRD; phosphoELM
Y717DDGDSyGFITYRRM_1PhosphoSitePlus
S787SLDFDsLLKEAPhosphoSitePlus
T295GTAGLtPPTTPPhosphoSitePlus
S266PLTPEsPNDPKp38a(MAPK14RegPhos
S266PLTPEsPNDPKp38_groupphosphoELM; RegPhos
T299LTPPTtPPHKAMAPK14HPRD; phosphoELM
Y634SRRPRyDSYEEPhosphoSitePlus
S571RSRSRsFSRHRPhosphoSitePlus
T263LSLPLtPESPNp38_groupphosphoELM; RegPhos
S313NPFRAsPKLKSPhosphoSitePlus
T299LTPPTtPPHKAp38_groupphosphoELM; RegPhos
T721SYGFItYRYTCRRM_1PhosphoSitePlus
S266PLTPEsPNDPKPhosphoSitePlus
S285IERTLsVELSGPhosphoSitePlus
T299LTPPTtPPHKAPhosphoSitePlus
T263LSLPLtPESPNPhosphoSitePlus

Dephosphorylation site
PRGC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264867G348RCOSMICOvarian Cancer21720365
ENSP00000264867E353KCOSMICSkin Cancer21984974
ENSP00000264867Q431HCOSMICLung Cancer
ENSP00000264867P267RCOSMICLung Cancer
ENSP00000264867P264QCOSMICSkin Cancer21984974
ENSP00000264867P446SCOSMICSkin Cancer21984974
ENSP00000264867G467DCOSMICMelanoma21499247
ENSP00000264867R797HCOSMICOvarian Cancer21720365
ENSP00000264867S626LCOSMICMelanoma21499247

Differential expressed protein
PRGC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PRGC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANPRGC1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
FOXO1_HUMANPRGC1_HUMANotherKEGG
STAT3_HUMANPRGC1_HUMANTF -> target geneKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa05016Huntington's disease
hsa04920Adipocytokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0035066positive regulation of histone acetylationTASbiological_process
GO:2000310regulation of N-methyl-D-aspartate selective glutaIEAbiological_process
GO:0001659temperature homeostasisTASbiological_process
GO:0005634nucleusISScellular_component
GO:0008134transcription factor bindingTASmolecular_function
GO:0050821protein stabilizationTASbiological_process
GO:0014850response to muscle activityIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0045333cellular respirationTASbiological_process
GO:0070997neuron deathIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0022904respiratory electron transport chainISSbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIEAbiological_process
GO:0042594response to starvationNASbiological_process
GO:0006397mRNA processingTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0030374ligand-dependent nuclear receptor transcription coIDAmolecular_function
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0006461protein complex assemblyTASbiological_process
GO:0003713transcription coactivator activityIEAmolecular_function
GO:0014823response to activityIEAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0070925organelle assemblyISSbiological_process
GO:0050873brown fat cell differentiationTASbiological_process
GO:0034599cellular response to oxidative stressIEAbiological_process
GO:0045722positive regulation of gluconeogenesisTASbiological_process
GO:0007005mitochondrion organizationNASbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0008380RNA splicingTASbiological_process
GO:0014850response to muscle activityISSbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0019395fatty acid oxidationNASbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0001678cellular glucose homeostasisNASbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0007586digestionTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0031490chromatin DNA bindingISSmolecular_function
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0046321positive regulation of fatty acid oxidationTASbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:2000507positive regulation of energy homeostasisISSbiological_process
GO:0001104RNA polymerase II transcription cofactor activityTASmolecular_function
GO:0005665DNA-directed RNA polymerase II, core complexTAScellular_component
GO:0003723RNA bindingTASmolecular_function
GO:0043524negative regulation of neuron apoptotic processISSbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0034599cellular response to oxidative stressISSbiological_process
GO:0046321positive regulation of fatty acid oxidationIEAbiological_process
GO:0007005mitochondrion organizationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:2001171positive regulation of ATP biosynthetic processISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0022904respiratory electron transport chainIEAbiological_process
GO:0016922ligand-dependent nuclear receptor bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0006094gluconeogenesisNASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0010941regulation of cell deathIDAbiological_process