| UniProt/SwissProt ID: | NFM_HUMAN |
| Description: | neurofilament, medium polypeptide [Source:HGNC Symbol;Acc:7734] |
| Location: | chr8 p21.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S659 | SPVPKsPVEEK | PhosphoSitePlus; phosphoELM | |
| S633 | SPVPKsPVEEK | PhosphoSitePlus; phosphoELM | |
| S545 | DEGAKsDQAEE | PhosphoSitePlus | |
| S837 | NGLDLsPADEK | PhosphoSitePlus | |
| S511 | VAAKKsPVKAT | PhosphoSitePlus; phosphoELM | |
| S783 | GGEGGsEEEGS | PhosphoSitePlus; phosphoELM | |
| S646 | SPVPKsPVEEK | PhosphoSitePlus | |
| S558 | SEKEGsSEKEE | PhosphoSitePlus | |
| Y872 | DGATKyITKSV | PhosphoSitePlus | |
| Y384 | RHLREyQDLLN | Filament | PhosphoSitePlus |
| S28 | SFSRVsGSPSS | Filament_head | PhosphoSitePlus |
| S553 | AEEGGsEKEGS | PhosphoSitePlus | |
| S667 | EEKGKsPVSKS | PhosphoSitePlus; phosphoELM | |
| S628 | EEKGKsPVPKS | PhosphoSitePlus; phosphoELM | |
| S73 | LSSAEsSLDFS | Filament_head | PhosphoSitePlus |
| S30 | SRVSGsPSSGF | Filament_head | PhosphoSitePlus |
| S680 | EEKAKsPVPKS | PhosphoSitePlus; phosphoELM | |
| S670 | GKSPVsKSPVE | PhosphoSitePlus | |
| S226 | DKKVQsLQDEV | Filament | PhosphoSitePlus |
| S672 | SPVSKsPVEEK | PhosphoSitePlus; phosphoELM | |
| S736 | KKKAEsPVKEE | PhosphoSitePlus; phosphoELM | |
| S654 | EEKGKsPVPKS | PhosphoSitePlus; phosphoELM | |
| S467 | VEDEKsEMEEA | PhosphoSitePlus | |
| Y401 | IEIAAyRKLLE | Filament | PhosphoSitePlus |
| S620 | SPVPKsPVEEK | PhosphoSitePlus; phosphoELM | |
| S641 | EEKGKsPVPKS | PhosphoSitePlus | |
| S33 | SGSPSsGFRSQ | Filament_head | PhosphoSitePlus |
| S615 | PEKAKsPVPKS | PhosphoSitePlus; phosphoELM | |
| S788 | SEEEGsDKGAK | PhosphoSitePlus; phosphoELM | |
| S685 | SPVPKsPVEEA | PhosphoSitePlus; phosphoELM | |
| S37 | SSGFRsQSWSR | Filament_head | PhosphoSitePlus |
| S559 | EKEGSsEKEEG | PhosphoSitePlus | |
| S44 | SWSRGsPSTVS | Filament_head | PhosphoSitePlus |
| Dephosphorylation site |
| NFM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| NFM_HUMAN do not have mutation site. |
| Differential expressed protein |
| NFM_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S620 | AKSPVPKsPVEEKGK | Alzheimer's disease | 20624930 | PhosphoSitePlus | S672 | GKSPVSKsPVEEKAK | Alzheimer's disease | 20624930 | PhosphoSitePlus | S685 | AKSPVPKsPVEEAKS | Alzheimer's disease | 20624930 | PhosphoSitePlus | S788 | GGSEEEGsDKGAKGS | Alzheimer's disease | 20624930 | PhosphoSitePlus | S646 | GKSPVPKsPVEEKGK | Alzheimer's disease | 20624930 | PhosphoSitePlus | S837 | VTNGLDLsPADEKKG | Alzheimer's disease | 20624930 | PhosphoSitePlus | S783 | KAGGEGGsEEEGSDK | Alzheimer's disease | 20624930 | PhosphoSitePlus | S667 | PVEEKGKsPVSKSPV | Alzheimer's disease | 20624930 | PhosphoSitePlus | S736 | PEKKKAEsPVKEEAV | Alzheimer's disease | 20624930 | PhosphoSitePlus | S659 | GKSPVPKsPVEEKGK | Alzheimer's disease | 20624930 | PhosphoSitePlus | S680 | PVEEKAKsPVPKSPV | Alzheimer's disease | 20624930 | PhosphoSitePlus | S615 | EKPEKAKsPVPKSPV | Alzheimer's disease | 20624930 | PhosphoSitePlus | S641 | PVEEKGKsPVPKSPV | Alzheimer's disease | 20624930 | PhosphoSitePlus | S736 | PEKKKAEsPVKEEAV | Alzheimer's disease | 21828286 | PhosphoSitePlus | S685 | AKSPVPKsPVEEAKS | Alzheimer's disease | 21828286 | PhosphoSitePlus | S33 | Filament_head | RVSGSPSsGFRSQSW | Alzheimer's disease | 21828286 | PhosphoSitePlus |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK14_HUMAN | NFM_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05014 | Amyotrophic lateral sclerosis (ALS) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030424 | axon | TAS | cellular_component |
| GO:0005883 | neurofilament | IEA | cellular_component |
| GO:0030424 | axon | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005198 | structural molecule activity | IEA | molecular_function |
| GO:0005882 | intermediate filament | IEA | cellular_component |
| GO:0031594 | neuromuscular junction | IEA | cellular_component |
| GO:0008088 | axon cargo transport | IEA | biological_process |
| GO:0000226 | microtubule cytoskeleton organization | IEA | biological_process |
| GO:0031133 | regulation of axon diameter | IEA | biological_process |
| GO:0060052 | neurofilament cytoskeleton organization | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0043005 | neuron projection | IEA | cellular_component |
| GO:0045110 | intermediate filament bundle assembly | IEA | biological_process |
| GO:0005200 | structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0045104 | intermediate filament cytoskeleton organization | IEA | biological_process |