Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFM_HUMAN
Description:neurofilament, medium polypeptide [Source:HGNC Symbol;Acc:7734]
Location:chr8 p21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S659SPVPKsPVEEKPhosphoSitePlus; phosphoELM
S633SPVPKsPVEEKPhosphoSitePlus; phosphoELM
S545DEGAKsDQAEEPhosphoSitePlus
S837NGLDLsPADEKPhosphoSitePlus
S511VAAKKsPVKATPhosphoSitePlus; phosphoELM
S783GGEGGsEEEGSPhosphoSitePlus; phosphoELM
S646SPVPKsPVEEKPhosphoSitePlus
S558SEKEGsSEKEEPhosphoSitePlus
Y872DGATKyITKSVPhosphoSitePlus
Y384RHLREyQDLLNFilamentPhosphoSitePlus
S28SFSRVsGSPSSFilament_headPhosphoSitePlus
S553AEEGGsEKEGSPhosphoSitePlus
S667EEKGKsPVSKSPhosphoSitePlus; phosphoELM
S628EEKGKsPVPKSPhosphoSitePlus; phosphoELM
S73LSSAEsSLDFSFilament_headPhosphoSitePlus
S30SRVSGsPSSGFFilament_headPhosphoSitePlus
S680EEKAKsPVPKSPhosphoSitePlus; phosphoELM
S670GKSPVsKSPVEPhosphoSitePlus
S226DKKVQsLQDEVFilamentPhosphoSitePlus
S672SPVSKsPVEEKPhosphoSitePlus; phosphoELM
S736KKKAEsPVKEEPhosphoSitePlus; phosphoELM
S654EEKGKsPVPKSPhosphoSitePlus; phosphoELM
S467VEDEKsEMEEAPhosphoSitePlus
Y401IEIAAyRKLLEFilamentPhosphoSitePlus
S620SPVPKsPVEEKPhosphoSitePlus; phosphoELM
S641EEKGKsPVPKSPhosphoSitePlus
S33SGSPSsGFRSQFilament_headPhosphoSitePlus
S615PEKAKsPVPKSPhosphoSitePlus; phosphoELM
S788SEEEGsDKGAKPhosphoSitePlus; phosphoELM
S685SPVPKsPVEEAPhosphoSitePlus; phosphoELM
S37SSGFRsQSWSRFilament_headPhosphoSitePlus
S559EKEGSsEKEEGPhosphoSitePlus
S44SWSRGsPSTVSFilament_headPhosphoSitePlus

Dephosphorylation site
NFM_HUMAN do not have dephosphorylation site.

Mutation site
NFM_HUMAN do not have mutation site.

Differential expressed protein
NFM_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S620AKSPVPKsPVEEKGKAlzheimer's disease20624930PhosphoSitePlus
S672GKSPVSKsPVEEKAKAlzheimer's disease20624930PhosphoSitePlus
S685AKSPVPKsPVEEAKSAlzheimer's disease20624930PhosphoSitePlus
S788GGSEEEGsDKGAKGSAlzheimer's disease20624930PhosphoSitePlus
S646GKSPVPKsPVEEKGKAlzheimer's disease20624930PhosphoSitePlus
S837VTNGLDLsPADEKKGAlzheimer's disease20624930PhosphoSitePlus
S783KAGGEGGsEEEGSDKAlzheimer's disease20624930PhosphoSitePlus
S667PVEEKGKsPVSKSPVAlzheimer's disease20624930PhosphoSitePlus
S736PEKKKAEsPVKEEAVAlzheimer's disease20624930PhosphoSitePlus
S659GKSPVPKsPVEEKGKAlzheimer's disease20624930PhosphoSitePlus
S680PVEEKAKsPVPKSPVAlzheimer's disease20624930PhosphoSitePlus
S615EKPEKAKsPVPKSPVAlzheimer's disease20624930PhosphoSitePlus
S641PVEEKGKsPVPKSPVAlzheimer's disease20624930PhosphoSitePlus
S736PEKKKAEsPVKEEAVAlzheimer's disease21828286PhosphoSitePlus
S685AKSPVPKsPVEEAKSAlzheimer's disease21828286PhosphoSitePlus
S33Filament_headRVSGSPSsGFRSQSWAlzheimer's disease21828286PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
MK14_HUMANNFM_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030424axonTAScellular_component
GO:0005883neurofilamentIEAcellular_component
GO:0030424axonIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005198structural molecule activityIEAmolecular_function
GO:0005882intermediate filamentIEAcellular_component
GO:0031594neuromuscular junctionIEAcellular_component
GO:0008088axon cargo transportIEAbiological_process
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0031133regulation of axon diameterIEAbiological_process
GO:0060052neurofilament cytoskeleton organizationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0045110intermediate filament bundle assemblyIEAbiological_process
GO:0005200structural constituent of cytoskeletonTASmolecular_function
GO:0045104intermediate filament cytoskeleton organizationIEAbiological_process


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